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Submit ReviewCP 775146
说明： Selective, high affinity PPARα agonist
化学名： 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid
纯度： ≥99% (HPLC)
生物活性 for CP 775146
CP 775146 is a selective, high affinity PPARα agonist (Ki values are 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Exhibits hypolipidemic activity in vivo.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for CP 775146
CP 775146 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CP 775146
| 分子量 | 423.54 |
| 公式 | C26H33NO4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 702680-17-9 |
| PubChem ID | 10410059 |
| InChI Key | OISHBINQIFNIPV-JOCHJYFZSA-N |
| Smiles | O=C(CC3=CC=C(C(C)C)C=C3)N(C2)CCC[C@H]2[C@@]1=CC(OC(C)(C)C(O)=O)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CP 775146
参考文献 for CP 775146
参考文献是支持产品生物活性的出版物。
Kane et al (2009) Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo. Mol.Pharmacol. 75 296 PMID: 18971326
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关键词: CP 775146, CP 775146 supplier, pfizer, CP775146, pparalpha, ppara, pparα, peroxisome, proliferator-activated, receptors, agonists, selective, hypolipidemic, hypolipidaemic, PPARalpha, Receptors, 4190, Tocris Bioscience
1 篇 CP 775146 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CP 775146 的部分引用包括：
Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. Hum Mol Genet 10 e0120295 PMID: 25811180
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