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Submit ReviewCP 93129 dihydrochloride
说明： 5-HT1B agonist
化学名： 1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride
生物活性 for CP 93129 dihydrochloride
CP 93129 dihydrochloride is a potent and highly selective 5-HT1B agonist (Ki values are 8.1, 1100, 1500, 2900 and 7200 nM for 5-HT1B, 5-HT1D, 5-HT1A, 5-HT1c and 5-HT2, respectively). Reduces food intake and decreases body weight in rats.
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for CP 93129 dihydrochloride
| 分子量 | 288.18 |
| 公式 | C12H13N3O.2HCl |
| 储存 | Desiccate at RT |
| CAS Number | 879089-64-2 |
| PubChem ID | 46927988 |
| InChI Key | FLVJHUZZKVJQNH-UHFFFAOYSA-N |
| Smiles | Cl.Cl.O=C1NC2=C(NC=C2C2=CCNCC2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CP 93129 dihydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.82 | 100 | |
| water | 28.82 | 100 |
制备储备液 for CP 93129 dihydrochloride
以下数据基于产品分子量 288.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.47 mL | 17.35 mL | 34.7 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 10 mM | 0.35 mL | 1.74 mL | 3.47 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.69 mL |
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产品说明书 for CP 93129 dihydrochloride
参考文献 for CP 93129 dihydrochloride
参考文献是支持产品生物活性的出版物。
Lee et al (1998) Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology 136 304 PMID: 9566817
Koe et al (1992) Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Development Research 26 241
Hamid et al (2014) Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesicle complex. J Neurosci. 34 260 PMID: 24381287
If you know of a relevant reference for CP 93129 dihydrochloride, please let us know.
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关键词: CP 93129 dihydrochloride, CP 93129 dihydrochloride supplier, 5-HT1B, agonist, Serotonin, Receptors, CP93129, dihydrochloride, Pfizer, 1032, Tocris Bioscience
9 篇 CP 93129 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CP 93129 dihydrochloride 的部分引用包括：
Medrihan et al (2017) Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron 95 564 PMID: 28735749
Watakabe et al (2009) Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses. Neuron 19 1915 PMID: 19056862
Zhou et al (2019) Modulation of Kalirin-7 Expression by Hippocampal CA1 5-HT1B Receptors in Spatial Memory Consolidation. Behav Brain Res 356 148 PMID: 29949735
Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552
Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Cereb Cortex 3 e00103 PMID: 25692021
Guo and Rainnie (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165 1390 PMID: 19963045
Majeed et al (2016) Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster. Neural Plast 2016 7291438 PMID: 26989517
Heisler et al (2006) Serotonin reciprocally regulates melanocortin neurons to modulate food intake. J Pharmacol Exp Ther 51 239 PMID: 16846858
Rau et al (2006) Methamphetamine administration reduces hippocampal vesicular monoamine transporter-2 uptake. Exp Ther Med 318 676 PMID: 16687477
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CP 93129 dihydrochloride 的评论
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Modulation of spontaneous interneuronal signalling.
By
Sergiy Sylantyev on 12/10/2023
分析类型： In Vitro
种属： Mouse
细胞系/组织： Arcuate nucleus
CP 93129 was used to modulate spontaneous generation of action potentials in neurons of arcuate nucleus. Illustration: application of 100 nM CP 93129 (grey bar) decreases frequency of AP generation in living neuron.
5-HT has a potential for relaxant.
By
Anonymous on 02/18/2020
分析类型： In Vivo
种属： Rat
CP93129 (5-HT1B)10nM
Antidepressantsby Cholecystokinin Neurons of the Dentate Gyrus.
By
Anonymous on 02/03/2020
分析类型： In Vivo
种属： Mouse
CP (10mM)
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.