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Submit ReviewCP 945598 hydrochloride
说明： CB1 antagonist
化学名： 1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for CP 945598 hydrochloride
CP 945598 hydrochloride is a selective, high affinity CB1 antagonist (Ki values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB2 receptors (Ki = 7600 nM).
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for CP 945598 hydrochloride
| 分子量 | 546.88 |
| 公式 | C25H25Cl2N7O.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 686347-12-6 |
| PubChem ID | 16223963 |
| InChI Key | KPYUQCJBZGQHPL-UHFFFAOYSA-N |
| Smiles | CCNC(CC4)(C(N)=O)CCN4C1=NC=NC2=C1N=C(C5=C(Cl)C=CC=C5)N2C3=CC=C(Cl)C=C3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CP 945598 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 10.94 | 20 |
制备储备液 for CP 945598 hydrochloride
以下数据基于产品分子量 546.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 9.14 mL | 45.71 mL | 91.43 mL |
| 1 mM | 1.83 mL | 9.14 mL | 18.29 mL |
| 2 mM | 0.91 mL | 4.57 mL | 9.14 mL |
| 10 mM | 0.18 mL | 0.91 mL | 1.83 mL |
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产品说明书 for CP 945598 hydrochloride
参考文献 for CP 945598 hydrochloride
参考文献是支持产品生物活性的出版物。
Griffith et al (2009) Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J.Med.Chem. 52 234 PMID: 19102698
Hadcock et al (2010) In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochem.Biophys.Res.Commun. 394 366 PMID: 20211605
If you know of a relevant reference for CP 945598 hydrochloride, please let us know.
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关键词: CP 945598 hydrochloride, CP 945598 hydrochloride supplier, CP945598, cannabinoid, receptors, cb1, antagonists, pfizer, CB1, Receptors, 4236, Tocris Bioscience
1 篇 CP 945598 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CP 945598 hydrochloride 的部分引用包括：
Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731
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