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CPT 11

Cat. No. 2688 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： DNA topoisomerase I inhibitor; antitumor
别名： Irinotecan,Camptothecin 11
化学名： (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CPT 11

CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).

化合物库 for CPT 11

CPT 11 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for CPT 11

分子量 623.14
公式 C33H38N4O6.HCl
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 100286-90-6
PubChem ID 74990
InChI Key GURKHSYORGJETM-WAQYZQTGSA-N
Smiles CCC2=C4C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)=NC1=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C12.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CPT 11

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 3.12 5 温和加热
DMSO 62.31 100

制备储备液 for CPT 11

以下数据基于产品分子量 623.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.6 mL 8.02 mL 16.05 mL
5 mM 0.32 mL 1.6 mL 3.21 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Molarity Calculator

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Reconstitution Calculator

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产品说明书 for CPT 11

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for CPT 11

参考文献是支持产品生物活性的出版物。

Kawato et al (1993) Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. J.Pharm.Pharmacol. 45 444 PMID: 8099964

Vassal et al (1996) Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br.J.Cancer. 74 537 PMID: 8761367

Morton et al (2005) Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice. Can.Chemother.Pharmacol. 56 629 PMID: 15918039

If you know of a relevant reference for CPT 11, please let us know.

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关键词: CPT 11, CPT 11 supplier, DNA, topoisomerase, I, inhibitors, inhibits, antitumor, Isomerases, CPT11, Camptothecin11, chemotherapeutics, Irinotecan, Camptothecin, 11, Topoisomerase, 2688, Tocris Bioscience

1 篇 CPT 11 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CPT 11 的部分引用包括：

Schnúr et al (2019) Phosphorylation-dependent modulation of CFTR macromolecular signalling complex activity by cigarette smoke condensate in airway epithelia. Sci Rep 9 12706 PMID: 31481727

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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