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Submit ReviewCRF (6-33) is a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo.
Sold with the permission of the SALK Institute
分子量 | 3220.68 |
公式 | C141H231N41O43S |
序列 | ISLDLTFHLLREVLEMARAEQLAQQAHS |
储存 | Desiccate at -20°C |
CAS Number | 120066-38-8 |
PubChem ID | 16135485 |
InChI Key | XHHPINGDTRCKNN-QZXFXOMNSA-N |
Smiles | [H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(O)=O |
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参考文献是支持产品生物活性的出版物。
Heinrichs et al (2001) Dissociation of arousal-like from anxiogenic-like actions of brain corticotropin-releasing factor receptor ligands in rats. Behav.Brain Res. 122 43 PMID: 11287075
Heinrichs et al (2001) Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol.Behav. 74 5 PMID: 11564446
Jahn et al (2002) The binding protein of corticotropin-releasing factor: ligand-binding site and subunit structure. Proc.Natl.Acad.Sci.U.S.A. 99 12055 PMID: 12215497
关键词: CRF (6-33), CRF (6-33) supplier, CRF-binding, protein, inhibitors, inhibits, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Corticotropin, Releasing, (6-33), Non-selective, CRF, 1607, Tocris Bioscience
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.