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CRF Receptors

Corticotropin-releasing factor (CRF), also known as corticotropin-releasing hormone, is a major regulator of homeostasis, mediating the autonomic, behavioral and neuroendocrine responses to stress. CRF has also been suggested to play a role in cell growth and survival. To date, two types of CRF receptors have been cloned from several mammals: CRF1 and CRF2 receptors. Two splice variants of the CRF2 receptor have been identified in rodents; CRF2a and CRF2b.

Targets
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Receptor Data

CRF Receptor Target Files

Related Targets

    Literature for CRF Receptors

    Tocris offers the following scientific literature for CRF Receptors to showcase our products. We invite you to request* your copy today!

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    Depression Poster

    Depression Poster

    Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

    CRF Receptor Data

    Receptor Subtype CRF1 CRF2a CRF2b
    Transduction Mechanism Activates Gs Activates Gs Activates Gs

    Key Compounds Ki (nM)
    Agonists CRF (human, rat) (1151)
    Urocortin (rat) (1605)
    Sauvagine (1609)
    Stressin I (1608)     		11
    13
    9.4
    1.5     		44
    1.5
    9.9
    224     		38
    0.97
    3.8
    224
    Antagonists Astressin (1606)
    α-helical CRF 9-41 (1184)
    NBI 27914 (1591)
    CP 154526 (2779)
    CP 376395 (3212)
    K 41498 (2070)     		2
    17
    2
    2.7
    12
    425     		1.5
    5
    > 10000
    > 10000
    > 10000
    0.66     		1
    0.97
    -
    > 10000
    > 10000
    0.62

    References

    Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. Maciejewski-Lenoir et al (200) Selective impairment of corticotropin-releasing factor1 (CRF1) receptor-mediated function using CRF coupled to saporin. Endocrinology 141 498.