Crizotinib

Cat. No. 4368 9 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent c-MET/ALK inhibitor

别名： PF 02341066,PF 2341066

化学名： 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine

纯度： ≥99% (HPLC)

引用文献 (9)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Crizotinib

Crizotinib is a potent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC₅₀ values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for Crizotinib

分子量	450.34
公式	C₂₁H₂₂Cl₂FN₅O
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	877399-52-5
PubChem ID	11626560
InChI Key	KTEIFNKAUNYNJU-GFCCVEGCSA-N
Smiles	ClC1=[C@@]([C@H](OC2=C(N)N=CC(C3=CN(C4CCNCC4)N=C3)=C2)C)C(Cl)=CC=C1F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Crizotinib

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	4.5	10
	2eq.HCl	45.03	100

制备储备液 for Crizotinib

以下数据基于产品分子量 450.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.1 mL	22.21 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for Crizotinib

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Crizotinib

参考文献是支持产品生物活性的出版物。

Christensen et al (2007) Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol.Cancer Ther. 6 3314 PMID: 18089725

Zou et al (2007) An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 67 4408 PMID: 17483355

Cui et al (2011) Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J.Med.Chem. 54 6342 PMID: 21812414

If you know of a relevant reference for Crizotinib, please let us know.

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关键词: Crizotinib, Crizotinib supplier, c-MET, alk, anaplastic, lymphoma, kinases, antitumor, selective, potent, PF2341066, PF02341066, PF, 02341066, 2341066, MET, Receptors, ALK, 4368, Tocris Bioscience