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CST 905

Cat. No. 7745 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective BRAFV600E Degrader (PROTAC®)
化学名： (2S,4R)-1-((S)-2-(2-(4-(4-(3-(3-((N-Ethyl-N-methylsulfamoyl)amino)-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CST 905

CST 905 is a potent and selective BRAFV600E Degrader (PROTAC®) (DC50 = 18 nM). CST 905 comprises a ligand for the von Hippel Lindau (VHL) E3 ligase joined by a linker to a PLX-derived ligand. Unlike other BRAFV600E Degraders, CST 905 does not activate ERK.

B-Raf antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3424.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

技术数据 for CST 905

分子量 1025.2
公式 C51H58F2N10O7S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key VOFGLMSAVUMRLF-FGUOTCRGSA-N
Smiles FC1=C(C(F)=CC=C1NS(N(C)CC)(=O)=O)C(C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)N5CCN(CC5)CC(N[C@H](C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CST 905

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 102.52 100

制备储备液 for CST 905

以下数据基于产品分子量 1025.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.98 mL 4.88 mL 9.75 mL
5 mM 0.2 mL 0.98 mL 1.95 mL
10 mM 0.1 mL 0.49 mL 0.98 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for CST 905

参考文献是支持产品生物活性的出版物。

Miller et al (2022) Encoding BRAF inhibitor functions in protein degraders. RSC Med.Chem. 13 731 PMID: 35814929

If you know of a relevant reference for CST 905, please let us know.

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关键词: CST 905, CST 905 supplier, CST905, degraders, degradation, targeted, protein, degrader, E3, ligase, protac, BRAF, V600E, BRAFV600E, potent, selective, VHL, von, hippel, lindau, PLX, ERK, Raf, Kinase, and, Ras, Degraders, 7745, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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RAS Oncoproteins Scientific Review

Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia