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Submit ReviewCTCE 9908
说明： CXCR4 antagonist; antitumor
纯度： ≥95% (HPLC)
生物活性 for CTCE 9908
CTCE 9908 is a CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.
技术数据 for CTCE 9908
| 分子量 | 1927.27 |
| 公式 | C86H147N27O23 |
| 序列 |
KGVSLSYRK KGVSLSYR* (Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1030384-98-5 |
| PubChem ID | 90489012 |
| InChI Key | VUYRSKROGTWHDC-ICWZLGNASA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCCCC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N[H])CCCCN)C(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CTCE 9908
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for CTCE 9908
参考文献 for CTCE 9908
参考文献是支持产品生物活性的出版物。
Kwong et al (2009) An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol.Cancer Ther. 8 1893 PMID: 19567818
Hassan et al (2011) CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or doce. in a transgenic mouse model. Int.J.Cancer. 129 225 PMID: 20830712
Faber et al (2007) The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J.Biomed.Biotechnol. 2007 26065 PMID: 17541466
If you know of a relevant reference for CTCE 9908, please let us know.
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关键词: CTCE 9908, CTCE 9908 supplier, CTCE9908, CXCR4, receptor, chemokines, antagonists, ovarian, cancer, mitotic, catastrophe, mitosis, Mitosis, Chemokine, CXC, Receptors, 5130, Tocris Bioscience
1 篇 CTCE 9908 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CTCE 9908 的部分引用包括：
Ludger et al (2020) Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Sci Rep 10 16036 PMID: 32994431
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