Mitosis
Mitosis is a highly complex and regulated sequence of events that occurs exclusively in eukaryotic cells and produces two identical daughter cells from a single parent cell. It is split into five phases; prophase, prometaphase, metaphase, anaphase and telophase.
Mitosis Inhibitors |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 7734 | proTAME |
| Cell-permeable APC/C inhibitor | |
Other |
|
| Cat. No. | Product Name / Activity |
| 7865 | AMG 900 |
| Potent and selective pan-Aurora kinases inhibitor | |
| 6923 | AMZ 30 |
| Induces shortening of mitotic spindles and mitotic arrest; PME-1 inhibitor | |
| 5747 | Apcin |
| Cdc20 inhibitor; inhibits Cdc20-substrate interaction | |
| 5736 | Aphidicolin |
| DNA polymerase α, δ and ε inhibitor; antimitotic | |
| 7549 | BAY 1816032 |
| Potent and selective BUB1 kinase inhibitor | |
| 5399 | BTB1 |
| Selective and ATP-competitive Kif18A inhibitor | |
| 5687 | Centrinone |
| High affinity and selective PLK4 inhibitor | |
| 5690 | Centrinone B |
| High affinity and selective PLK4 inhibitor | |
| 1364 | Colchicine |
| Inhibitor of tubulin | |
| 5130 | CTCE 9908 |
| CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells | |
| 2897 | Dynasore |
| Non-competitive dynamin inhibitor | |
| 2226 | Flutax 1 |
| Fluorescent taxol derivative; binds microtubules | |
| 6254 | Flutax 2 |
| Green fluorescent taxol derivative; binds microtubules | |
| 2977 | GW 843682X |
| Selective inhibitor of PLK1 and PLK3 | |
| 3728 | Indibulin |
| Microtubule destabilizer | |
| 3982 | Mdivi 1 |
| Selective dynamin inhibitor; attentuates mitochondrial division | |
| 1305 | Monastrol |
| Selective inhibitor of mitotic kinesin Eg5 | |
| 1228 | Nocodazole |
| Microtubule inhibitor | |
| 5403 | TAK 960 hydrochloride |
| Potent and selective PLK1 inhibitor | |
| 1097 | Taxol |
| Promotes assembly and inhibits disassembly of microtubules | |
| 4459 | TC-S 7005 |
| Potent and selective PLK2 inhibitor | |
| 2191 | S-Trityl-L-cysteine |
| Potent, selective inhibitor of mitotic kinesin Eg5 | |
| 1256 | Vinblastine sulfate |
| Disrupts microtubules | |
| 1257 | Vincristine sulfate |
| Disrupts microtubules | |
| 1232 | Wortmannin |
| Potent inhibitor of PLK1. Also inhibitor of PI 3-kinase | |
| 2458 | ZM 447439 |
| Inhibits Aurora kinase B | |
Mitosis is a highly complex and regulated sequence of events that occurs exclusively in eukaryotic cells and produces two identical daughter cells from a single parent cell.
Mitosis is split into five phases:
- Prophase - Chromatin condenses to form chromosomes. Centrosomes begin to migrate to opposite poles of the cell.
- Prometaphase - The nuclear envelope breaks down and centrosomes are situated at opposite poles of the cell. Sister chromatids attach to the microtubule spindles.
- Metaphase - Chromosomes align along the equatorial plane.
- Anaphase - The sister chromatids separate and are pulled to opposite poles of the cell along the microtubule spindles.
- Telophase - A new nuclear envelope forms around each set of sister chromatids. The chromatids decondense to chromatin and mitotic spindles start to break down.
Cytokinesis is a separate process that follows mitosis in order to complete cell division. It involves cleavage of the cytoplasm due to contraction of actin microfilaments that form a ring around the equator of the cell. This results in the formation of two daughter cells, each identical to the parent, that enter interphase at G0.
Literature for Mitosis
Tocris offers the following scientific literature for Mitosis to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
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