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CTPI 2

Cat. No. 7794 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective mitochondrial citrate transporter (SLC25A1) inhibitor
化学名： 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CTPI 2

CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.

技术数据 for CTPI 2

分子量 356.74
公式 C13H9ClN2O6S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 68003-38-3
InChI Key NJTHPOSQGFJTDP-UHFFFAOYSA-N
Smiles O=C(O)C=1C=CC=CC1NS(=O)(=O)C2=CC=C(Cl)C(=C2)N(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CTPI 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.67 100
ethanol 7.13 20

制备储备液 for CTPI 2

以下数据基于产品分子量 356.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.8 mL 14.02 mL 28.03 mL
5 mM 0.56 mL 2.8 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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参考文献 for CTPI 2

参考文献是支持产品生物活性的出版物。

Tan et al (2020) Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 27 2143 PMID: 31959914

Fernandez et al (2018) The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 25 1239 PMID: 29651165

Batchuluun et al (2022) Lipogenesis inhibitors: therapeutic opportunities and challenges. Nat.Rev.Drug Discov. 21 283 PMID: 35031766

If you know of a relevant reference for CTPI 2, please let us know.

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关键词: CTPI 2, CTPI 2 supplier, CTPI-2, selective, inhibitor, inhibits, mitochondrial, citrate, transporter, SLC25A1, steatohepatitis, glycolysis, carrier, Other, Ion, Pumps/Transporters, 7794, Tocris Bioscience

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