CU CPT 22

Cat. No. 4884 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective TLR1/2 inhibitor

化学名： 3,4,6-Trihydroxy-2-methoxy-5-oxo-5H-benzocycloheptene-8-carboxylic acid hexyl ester

纯度： ≥98% (HPLC)

引用文献 (5)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CU CPT 22

CU CPT 22 is a selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC₅₀ = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and TLR7 or a panel of 10 representative kinases. Inhibits the release of proinflammatory cytokines TNF-α and IL-1β.

许可信息

Sold under license from the University of Colorado

技术数据 for CU CPT 22

分子量	362.37
公式	C₁₉H₂₂O₇
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1416324-85-0
PubChem ID	71503400
InChI Key	UBQFTTUFRSSOHE-UHFFFAOYSA-N
Smiles	O=C1C(O)=CC(C(OCCCCCC)=O)=CC2=C1C(O)=C(O)C(OC)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CU CPT 22

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	36.24	100

制备储备液 for CU CPT 22

以下数据基于产品分子量 362.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.8 mL	27.6 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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产品说明书 for CU CPT 22

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CU CPT 22

参考文献是支持产品生物活性的出版物。

Cheng et al (2012) Discovery of small-molecule inhibitors of the TLR1/TLR2 complex. Angew Chem.Int.Ed.Engl. 51 12246 PMID: 22969053

If you know of a relevant reference for CU CPT 22, please let us know.

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Toll-like Receptors

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关键词: CU CPT 22, CU CPT 22 supplier, CUCPT22, toll-like, receptors, inhibitors, inhibits, selective, proinflammatory, cytokines, TLR, TLR1, TLR2, TRL1/TLR2, Toll-like, Receptors, 4884, Tocris Bioscience

5 篇 CU CPT 22 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CU CPT 22 的部分引用包括：

Pietro et al (2022) Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapy. Oncoimmunology 11 2086752 PMID: 35756841

Ghonime et al (2015) Inflammasome priming is similar for francisella species that differentially induce inflammasome activation. Nucleic Acids Res 10 e0127278 PMID: 25993107

Ahn et al (2019) Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res 43 291 PMID: 30976167

Balachandar et al (2020) Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci 16 3062-3074 PMID: 33061818

Avadhesha et al (2023) TLR4 activation by lysozyme induces pain without inflammation. Front Immunol 14 1065226 PMID: 37197666

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Pathways for CU CPT 22

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.