主页 / 药理学 / Enzymes / Dehydrogenases / Aldehyde Dehydrogenases / Aldehyde Dehydrogenase Inhibitors / CVT 10216

CVT 10216

Cat. No. 5164 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective ALDH2 inhibitor
化学名： 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CVT 10216

CVT 10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.

化合物库 for CVT 10216

CVT 10216 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CVT 10216

分子量 465.48
公式 C24H19NO7S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1005334-57-5
PubChem ID 23661666
InChI Key YYOOFJZTRCPVFD-UHFFFAOYSA-N
Smiles O=C2C1=CC=C(OCC4=CC(C(O)=O)=CC=C4)C=C1OC=C2C3=CC=C(NS(=O)(C)=O)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CVT 10216

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.55 100
1eq. NaOH 23.27 50

制备储备液 for CVT 10216

以下数据基于产品分子量 465.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for CVT 10216

参考文献是支持产品生物活性的出版物。

Overstreet et al (2009) A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol.Biochem.Behav. 94 255 PMID: 19747934

Yao et al (2010) Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of DA synthesis. Nat.Med. 16 1024 PMID: 20729865

If you know of a relevant reference for CVT 10216, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Aldehyde Dehydrogenase Inhibitors

关键词: CVT 10216, CVT 10216 supplier, CVT10216, potent, selective, reversible, inhibitors, inhibits, aldehyde, dehydrogenase, 2, ALDH2, anxiolytics, anti-anxiety, Aldehyde, Dehydrogenase, 5164, Tocris Bioscience

篇 CVT 10216 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 CVT 10216 的引用文献。 您是否知道使用了 Tocris CVT 10216 的优秀论文？ 请告知我们.

CVT 10216 的评论

目前没有该产品的评论。 Be the first to review CVT 10216 and earn rewards!

Have you used CVT 10216?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review