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CVT 313

Cat. No. 6174 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cdk2 and cdk5 inhibitor
化学名： 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for CVT 313

CVT 313 is a cyclin-dependent kinase 2 (cdk2) inhibitor (reported IC50 values are 0.18 to 0.5 μM). Also inhibits cdk5 in sub-micromolar range (IC50 = 0.42 μM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks. Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.

化合物库 for CVT 313

CVT 313 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for CVT 313

分子量 400.47
公式 C20H28N6O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 199986-75-9
PubChem ID 6918386
InChI Key NQVIIUBWMBHLOZ-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)CNC2=NC(N(CCO)CCO)=NC3=C2N=CN3C(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CVT 313

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.05 100
ethanol 40.05 100

制备储备液 for CVT 313

以下数据基于产品分子量 400.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.49 mL 24.97 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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参考文献 for CVT 313

参考文献是支持产品生物活性的出版物。

Brooks et al (1997) CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J.Biol.Chem. 272 29207 PMID: 9360999

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for CVT 313, please let us know.

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关键词: CVT 313, CVT 313 supplier, CVT313, cdk2, cyclin, dependent, kinase, 2, inhibitors, inhibits, neointimal, proliferation, restenosis, Cyclin-dependent, Kinase, Non-selective, CDKs, 6174, Tocris Bioscience

1 篇 CVT 313 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CVT 313 的部分引用包括：

Musa et al (2019) Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. Nat Commun 10 4128 PMID: 31511524

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