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Submit ReviewCX 614
说明： Positive allosteric modulator of AMPA receptors
化学名： 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one
纯度： ≥99% (HPLC)
生物活性 for CX 614
CX 614 is an AMPAkine; positive allosteric modulator of AMPA. Prototypical benzamide which occupies subsite A only. Modulates channel deactivation and desensitization.
化合物库 for CX 614
CX 614 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for CX 614
| 分子量 | 247.25 |
| 公式 | C13H13NO4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 191744-13-5 |
| PubChem ID | 6451148 |
| InChI Key | RQEPVMAYUINZRE-UHFFFAOYSA-N |
| Smiles | O=C2N4C(CCC4)OC1=CC3=C(OCCO3)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CX 614
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 24.73 | 100 | |
| ethanol | 12.36 | 50 |
制备储备液 for CX 614
以下数据基于产品分子量 247.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.04 mL | 20.22 mL | 40.44 mL |
| 5 mM | 0.81 mL | 4.04 mL | 8.09 mL |
| 10 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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产品说明书 for CX 614
参考文献 for CX 614
参考文献是支持产品生物活性的出版物。
Harms et al (2013) Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology 64 45 PMID: 22735771
Timm et al (2011) Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol. 80 267 PMID: 21543522
Hennegriff et al (1997) Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators. J.Neurochem. 68 2424 PMID: 9166736
If you know of a relevant reference for CX 614, please let us know.
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关键词: CX 614, CX 614 supplier, CX614, Positive, allosteric, modulators, AMPA, receptors, AMPAkines, benzamide, PAM, Receptors, 5149, Tocris Bioscience
3 篇 CX 614 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CX 614 的部分引用包括：
Susumu et al (2021) Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway. iScience 24 102504 PMID: 34113835
Carolina da Silveira et al (2021) Respiratory depression and analgesia by opioid drugs in freely behaving larval zebrafish. Elife 10 PMID: 33720013
Ege T et al (2021) A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. Cell Rep 36 109467 PMID: 34348149
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