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Submit ReviewCY 208-243
说明： Selective D1-like agonist
化学名： (-)-(6aR,12bR)-4,6,6a,7,8,12b-Hexahydro-7-methylindolo[4,3-a]phenanthridin
生物活性 for CY 208-243
CY 208-243 is a centrally active dopamine D1 receptor agonist, selective over D2 receptor sites. Stimulates adenylate cyclase in rat striatal homogenates with an EC50 of 125 nM. Unlike SKF 38393 (Cat. No. 0922), it exerts antiParkinsonian activity in animal models.
许可信息
Sold with the permission of Novartis Pharma AG
技术数据 for CY 208-243
| 分子量 | 274.36 |
| 公式 | C19H18N2 |
| 储存 | Store at RT |
| CAS Number | 100999-26-6 |
| PubChem ID | 58144 |
| InChI Key | WRNKIDLXXXIELU-IEBWSBKVSA-N |
| Smiles | [H][C@]4([C@@]([H])3C5=C(C=CC=C5)CN4C)CC1=CNC2=C1C3=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CY 208-243
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 100 |
制备储备液 for CY 208-243
以下数据基于产品分子量 274.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.64 mL | 18.22 mL | 36.45 mL |
| 5 mM | 0.73 mL | 3.64 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.64 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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产品说明书 for CY 208-243
参考文献 for CY 208-243
参考文献是支持产品生物活性的出版物。
Andersen and Jansen (1990) DA receptor agonists: selectivity and DA D1 receptor efficacy. Eur.J.Pharmacol. 188 335 PMID: 1973652
Temlett et al (1989) Antiparkinsonian activity of CY 208-243, a partial D-1 DA receptor agonist, in MPTP-treated marmosets and patients with Parkinson's disease. Mov.Disord. 4 261 PMID: 2571082
Markstein et al (1988) Pharmacologic properties of CY 208-243, a novel D1 agonist. Progress in Catecholamine Research. Part B. Centra 59-64
If you know of a relevant reference for CY 208-243, please let us know.
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关键词: CY 208-243, CY 208-243 supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, CY208-243, and, 1249, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.