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Submit ReviewCyanopindolol hemifumarate
说明： 5-HT1A and 5-HT1B antagonist; also β-adrenergic antagonist
化学名： 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate
纯度： ≥98% (HPLC)
生物活性 for Cyanopindolol hemifumarate
Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.
化合物库 for Cyanopindolol hemifumarate
Cyanopindolol hemifumarate is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Cyanopindolol hemifumarate
| 分子量 | 345.4 |
| 公式 | C16H21N3O2.½C4H4O4 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 69906-86-1 |
| PubChem ID | 45073413 |
| InChI Key | ZSBITJKBOWVCCI-WXXKFALUSA-N |
| Smiles | [H]OC(=O)\C=C\C(=O)O[H].CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N.CC(C)(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cyanopindolol hemifumarate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.54 | 100 |
制备储备液 for Cyanopindolol hemifumarate
以下数据基于产品分子量 345.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.9 mL | 14.48 mL | 28.95 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.79 mL |
| 10 mM | 0.29 mL | 1.45 mL | 2.9 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for Cyanopindolol hemifumarate
参考文献 for Cyanopindolol hemifumarate
参考文献是支持产品生物活性的出版物。
Engel et al (1986) Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 332 1 PMID: 2936965
Giles et al (1996) Characterization of a 5-HT1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br.J.Pharmacol. 117 1119 PMID: 8882605
Hoey et al (1996) Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br.J.Pharmacol. 117 712 PMID: 8646418
Blue et al (1989) Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum. Br.J.Pharmacol. 96 246P
If you know of a relevant reference for Cyanopindolol hemifumarate, please let us know.
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关键词: Cyanopindolol hemifumarate, Cyanopindolol hemifumarate supplier, 5-HT1A/1B, antagonists, β-adrenergic, beta-adrenergic, β-adrenoceptor, beta-adrenoceptor, b-adrenergic, b-adrenoceptor, Serotonin, 5-HT1A, Receptors, 5-HT1B, Non-selective, Adrenergic, Beta, 0993, Tocris Bioscience
4 篇 Cyanopindolol hemifumarate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cyanopindolol hemifumarate 的部分引用包括：
Gautam et al (2016) Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling. Mol Cancer 15 75 PMID: 27871326
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Pharmacol Exp Ther 329 350 PMID: 19144685
Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282
Brahmadevara et al (2004) ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta. Br J Pharmacol 142 781 PMID: 15205310
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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