Cyclosomatostatin

Cat. No. 3493 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Non-selective sst antagonist

别名： Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL])

纯度： ≥95% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cyclosomatostatin

Cyclosomatostatin is a non-selective somatostatin (sst) receptor antagonist. Blocks the effects of sst on airway β-adrenergic function, CRF-induced suppression of gastric empyting, modulation of ACh release and growth hormone, insulin and glucagon release. Reported to act as an sst receptor agonist in human neuroblastoma cell line SH-SY5Y.

技术数据 for Cyclosomatostatin

分子量	779.98
公式	C₄₄H₅₇N₇O₆
序列	FWKT (Modifications: Phe-1 = Aminoheptanoyl-Phe, Trp-2 = D-Trp, Thr-4 = Bn-Thr), lactam bridge: Phe-1 to Thr-4
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	84211-54-1
PubChem ID	122080
InChI Key	YHVHQZYJGWGAKN-ZUWUZHNASA-N
Smiles	C[C@@H](OCC1=CC=CC=C1)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)CCCCCCNC1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cyclosomatostatin

溶解性	Soluble to 1 mg/ml in 20% ethanol / water

产品说明书 for Cyclosomatostatin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cyclosomatostatin

参考文献是支持产品生物活性的出版物。

Fries et al (1982) Somatostatin antagonist analog increases GH, Ins, and glucagon release in the rat. Peptides 3 811 PMID: 6129618

Stirnweis et al (2002) The putative somatostatin antagonist, cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), may act as a potent antiproliferative agonist. Peptides 23 1503 PMID: 12182954

Guo et al (2008) Somatostatin inhibits activation of dorsal cutaneous primary afferents induced by antidromic stimulation of primary afferents from an adjacent segment in the rat. Brain Res. 1229 61 PMID: 18640104

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关键词: Cyclosomatostatin, Cyclosomatostatin supplier, Non-Selective, sst, receptor, antagonists, Receptors, Somatostatin, Cyclo-(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[BZL]), 3493, Tocris Bioscience