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Submit ReviewCyclotraxin B
说明： TrkB receptor antagonist
纯度： ≥95% (HPLC)
生物活性 for Cyclotraxin B
Cyclotraxin B is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice.
技术数据 for Cyclotraxin B
| 分子量 | 1200.36 |
| 公式 | C48H73N13O17S3 |
| 序列 |
CNPMGYTKEGC (Modification: Disulfide bridge: 1-11) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1203586-72-4 |
| PubChem ID | 90489002 |
| InChI Key | JLBMMJHZUYBFGX-ZHTCEXBHSA-N |
| Smiles | [H]N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cyclotraxin B
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for Cyclotraxin B
参考文献 for Cyclotraxin B
参考文献是支持产品生物活性的出版物。
Constandil et al (2012) Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J.Pain 13 579 PMID: 22560237
Cazorla et al (2010) Cyclotraxin-B, the first highly potent and selective TrkB antagonist, has anxiolytic properties in mice. PLoS One 5 e9777 PMID: 20333308
If you know of a relevant reference for Cyclotraxin B, please let us know.
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关键词: Cyclotraxin B, Cyclotraxin B supplier, anxiolytic, antagonists, TrkB, receptors, Trk, Receptors, 5062, Tocris Bioscience
2 篇 Cyclotraxin B 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cyclotraxin B 的部分引用包括：
Merk et al (2018) Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma. Dev Cell 44 709 PMID: 29551561
Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons. Oncotarget 35 4469 PMID: 25762688
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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