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Submit ReviewCYN 154806
说明： Selective sst2 antagonist
纯度： ≥95% (HPLC)
生物活性 for CYN 154806
CYN 154806 is a potent and selective somatostatin sst2 receptor antagonist. pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
技术数据 for CYN 154806
| 分子量 | 1197.35 |
| 公式 | C56H68N12O14S2 |
| 序列 |
FCYWKTCY (Modifications: Phe-1 = Ac-(4-nitro)Phe, Cys-2 = D-Cys, Trp-4 = D-Trp, Tyr-8 = D-Tyr & C-terminal amide, Disulfide bridge: 2-7) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 183658-72-2 |
| PubChem ID | 16133842 |
| InChI Key | RDTVTSXTFYXNSG-HDNDNHAUSA-N |
| Smiles | C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@H](CC1=CC=C(O)C=C1)C(N)=O)NC(=O)[C@H](CC1=CC=C(C=C1)[N+]([O-])=O)NC(C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for CYN 154806
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for CYN 154806
参考文献 for CYN 154806
参考文献是支持产品生物活性的出版物。
Bass et al (1996) Identification and characterization of novel somatostatin antagonists. Mol.Pharmacol. 50 709 PMID: 8863814
Feniuk et al (2000) Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology 39 1443 PMID: 10818260
Hannon et al (2002) Drug design at peptide receptors. Somatostatin receptor ligands. J.Mol.Neurosci. 18 15 PMID: 11931345
If you know of a relevant reference for CYN 154806, please let us know.
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关键词: CYN 154806, CYN 154806 supplier, Selective, sst2, antagonists, Receptors, Somatostatin, CYN154806, 1843, Tocris Bioscience
8 篇 CYN 154806 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CYN 154806 的部分引用包括：
Elliott et al (2015) Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263
Spitsin et al (2013) Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor. J Leukoc Biol 20 247 PMID: 23921645
Bowman et al (2019) Somatostatin 2 Receptors in the Spinal Cord Tonically Restrain Thermogenic, Cardiac and Other Sympathetic Outflows. Front Neurosci 13 121 PMID: 30842723
Iwagaki et al (2013) Neurochemical characterisation of lamina II inhibitory interneurons that express GFP in the PrP-GFP mouse. Mol Pain 9 56 PMID: 24176114
Yang et al (2010) Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159 1623 PMID: 20233224
Foong et al (2010) 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum. Neuroimmunomodulation 298 G384 PMID: 20007849
Paramonov et al (2018) Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?. Nanotheranostics 2 320 PMID: 30148051
Hastoy et al (2018) Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells. Sci Rep 8 16994 PMID: 30451893
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