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Submit ReviewCyPPA
说明： KCa2.2 and KCa2.3 (SK) channel activator
化学名： N-Cyclohexyl-N-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine
纯度： ≥99% (HPLC)
生物活性 for CyPPA
CyPPA is an activator of small conductance Ca2+-activated K+ channels that displays selectivity for KCa2.2 (SK2) and KCa2.3 (SK3) channels (EC50 values are 5.6 and 14 μM for KCa2.3 and KCa2.2 respectively). Displays no activity at KCa2.1 (SK1) and KCa3.1 (IK) channels.
技术数据 for CyPPA
| 分子量 | 285.39 |
| 公式 | C16H23N5 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 73029-73-9 |
| PubChem ID | 909822 |
| InChI Key | USEMRPYUFJNFQN-UHFFFAOYSA-N |
| Smiles | CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CyPPA
参考文献 for CyPPA
参考文献是支持产品生物活性的出版物。
Hougaard et al (2007) Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels. Br.J.Pharmacol. 151 655 PMID: 17486140
If you know of a relevant reference for CyPPA, please let us know.
关键词: CyPPA, CyPPA supplier, activators, SK2, SK3, channels, Potassium, KCa, KCa2.2, KCa2.3, Channels, ca2+-activated, ca2+-dependent, K+, SKCa2, SKCa3, Ca2+-Activated, 2953, Tocris Bioscience
2 篇 CyPPA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CyPPA 的部分引用包括：
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Abdulkareem et al (2016) Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. J Exp Clin Cancer Res 173 177 PMID: 26454020
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CyPPA 的评论
平均评分: 5 (Based on 1 Review.)
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CyPPA was used to study small conductance SK channel activation.
By
Eleanor Baxter on 10/23/2018
分析类型： In Vitro
种属： Human
CyPPA was used to study small conductance SK channel activation along with other activators as a measure of comparison. The compound shows reasonable calcium activated potassium channel opening.
