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Submit ReviewCyprodime hydrochloride
说明： Selective μ antagonist
化学名： 17-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Cyprodime hydrochloride
Cyprodime hydrochloride is a selective μ-opioid receptor antagonist (Ki values are 5.4, 244.6 and 2187 nM for μ-, δ- and κ-opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
技术数据 for Cyprodime hydrochloride
| 分子量 | 391.93 |
| 公式 | C22H29NO3.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2387505-50-0 |
| PubChem ID | 71628324 |
| InChI Key | MMOBYZBXXHEAAX-NCBCLDNOSA-N |
| Smiles | O=C3C[C@]24C1=C(OC)C=CC=C1C[C@@H](N(CC5CC5)CC4)[C@@](OC)2CC3.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Cyprodime hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.19 | 100 | |
| ethanol | 39.19 | 100 |
制备储备液 for Cyprodime hydrochloride
以下数据基于产品分子量 391.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.76 mL | 25.51 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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产品说明书 for Cyprodime hydrochloride
参考文献 for Cyprodime hydrochloride
参考文献是支持产品生物活性的出版物。
Schmidhammer et al (1995) Synthesis and biological evaluation of 14-alkoxymorphinans. 11. 3-hydroxycyprodime and analogues: opioid antagonist profile in comparison to cyprodime. J.Med.Chem. 38 3071 PMID: 7636870
Marki et al (1999) μ-opioid receptor specific antagonist cyprodime: characterization by in vitro radioligand and [35S]GTPγs binding assays. Eur.J.Pharmacol. 383 209 PMID: 10585536
Henry et al (2001) μ- and δ-opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Exp.Neurol. 171 139 PMID: 11520128
If you know of a relevant reference for Cyprodime hydrochloride, please let us know.
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关键词: Cyprodime hydrochloride, Cyprodime hydrochloride supplier, Selective, μ-opioid, mu-opioid, antagonists, MOP, Receptors, OP3, 118111-54-9, Mu, Opioid, 2601, Tocris Bioscience
2 篇 Cyprodime hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cyprodime hydrochloride 的部分引用包括：
Norris et al (2019) The Bivalent Rewarding and Aversive properties of δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal Modulation Mechanisms in Distinct Striatal Sub-Regions. Sci Rep 9 9760 PMID: 31278333
Lee et al (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. J Neurosci 2012 941685 PMID: 22645476
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