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Cysmethynil

Cat. No. 7337 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： ICMT inhibitor; arrests cell-cycle at G1 phase
化学名： 5-(3-Methylphenyl)-1-octyl-1H-indole-3-acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cysmethynil

Cysmethynil is an isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor (IC50 = 2.4 μM). Cysmethynil reduces growth of RAS-mutant cell lines in vitro and in vivo (EC50 = 20 μM) and reduces cell viability in a variety of cell lines (IC50 = 16.8-23.3 μM). Tumor growth, mTOR signaling and cell proliferation are inhibited by cysmethynil; apoptosis is induced. Cysmethynil increases p27 and p21 proteins and arrests cell-cycle at the G1 phase.

技术数据 for Cysmethynil

分子量 376.54
公式 C25H32N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 851636-83-4
PubChem ID 6918831
InChI Key QIXBOOVPFRZHQQ-UHFFFAOYSA-N
Smiles CCCCCCCCN1C=C(C2=CC(C3=CC(C)=CC=C3)=CC=C12)CC(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cysmethynil

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 37.65 100
DMSO 18.83 50

制备储备液 for Cysmethynil

以下数据基于产品分子量 376.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.56 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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参考文献 for Cysmethynil

参考文献是支持产品生物活性的出版物。

Moore et al (2020) RAS-targeted therapies: is the undruggable drugged? Nat.Rev.Drug Discov. 19 533 PMID: 32528145

Manu et al (2017) Inhibition of isoprenylcysteine carboxylmethyltransferase induces cell-cycle arrest and apoptosis through p21 and p21-regulated BNIP3 induction in pancreatic cancer. Mol.Cancer Ther. 16 914 PMID: 28167504

If you know of a relevant reference for Cysmethynil, please let us know.

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关键词: Cysmethynil, Cysmethynil supplier, ICMT, isoprenylcysteine, carboxymethyltransferase, inhibitors, inhibits, apoptosis, p27, p21, G1, cell, cycle, arrests, RAS, mutant, Other, Transferases, Cell, Cycle, Inhibitors, 7337, Tocris Bioscience

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