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Submit ReviewD-AP5
说明： Potent and selective NMDA receptor antagonist; more active form of DL-AP5
别名： 2-APV,D-APV,D-2-amino-5-phosphonovalerate
化学名： D-(-)-2-Amino-5-phosphonopentanoic acid
纯度： ≥99% (HPLC)
生物活性 for D-AP5
D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 is the more active isomer of DL-AP5 (Cat. No. 0105) and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection, D-AP5 results in rapid reduction of NMDA-response but no effect on spontaneously active neurons.
DL Mixture, L-isomer and sodium salt also available.
技术数据 for D-AP5
| 分子量 | 197.13 |
| 公式 | C5H12NO5P |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 79055-68-8 |
| PubChem ID | 135342 |
| InChI Key | VOROEQBFPPIACJ-SCSAIBSYSA-N |
| Smiles | N[C@@]([H])([C@](O)=O)CCCP(O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for D-AP5
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 19.71 | 100 |
制备储备液 for D-AP5
以下数据基于产品分子量 197.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.07 mL | 25.36 mL | 50.73 mL |
| 5 mM | 1.01 mL | 5.07 mL | 10.15 mL |
| 10 mM | 0.51 mL | 2.54 mL | 5.07 mL |
| 50 mM | 0.1 mL | 0.51 mL | 1.01 mL |
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产品说明书 for D-AP5
参考文献 for D-AP5
参考文献是支持产品生物活性的出版物。
Davies and Watkins (1982) Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res. 235 378 PMID: 6145492
Evans et al (1982) The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br.J.Pharmacol. 75 65 PMID: 7042024
Schulte et al (1994) Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634
Lodge et al (1988) A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists. Br.J.Pharmacol. 95 957 PMID: 2905186
If you know of a relevant reference for D-AP5, please let us know.
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关键词: D-AP5, D-AP5 supplier, Glutamate, NMDA, Receptors, antagonists, antagonises, N-Methyl-D-Aspartate, iGlu, Ionotropic, 2APV, D-APV, 2-APV, 2_APV, D_APV, DAPV, D-2-Amino-5-phosphonovalerate, excitatory, synaptic, transmission, electrophysiology, DAP5, AP5, 0106, Tocris Bioscience
372 篇 D-AP5 的引用文献
引用文献是使用了 Tocris 产品的出版物。 D-AP5 的部分引用包括：
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Neuron glia culture.
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Anonymous on 07/12/2020
分析类型： In Vitro
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Anonymous on 04/04/2020
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We delivered this drug intracranially in combination with DNQX to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.
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Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.