(d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

Cat. No. 3377 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective vasopressin V_1A antagonist

纯度： ≥95% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

(d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin is a selective vasopressin V_1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC₅₀ values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.

技术数据 for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

分子量	1151.38
公式	C₅₂H₇₄N₁₄O₁₂S₂
序列	XYFQNCPRG (Modifications: X = Pmp, Tyr-2 = Tyr(Me), Disulfide bridge: 1-6, Gly-9 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	73168-24-8
PubChem ID	122173055
InChI Key	QVQOGNOOAMQKCE-LOVRMFBOSA-N
Smiles	COC1=CC=C(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC2=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

溶解性	Soluble to 2 mg/ml in water

产品说明书 for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin

参考文献是支持产品生物活性的出版物。

Kruszynski et al (1980) [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(β-mercapto-β,β-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vas J.Med.Chem. 23 364 PMID: 6892930

Spath et al (1996) Arginine vasopressin and oxyt. increase intracellular calcium and cAMP in human glomerular epithelial cells in culture. Kidney Blood Press.Res. 19 81 PMID: 8871886

Tsuchiya et al (2002) Vasopressin inhibits sarcolemmal ATP-sensitive K⁺ channels via V₁ receptors activation in the guinea pig heart. Circ.J. 66 277 PMID: 11922278

Engin and Treit (2008) Dissociation of the anxiolytic-like effects of Avpr1a and Avpr1b receptor antagonists in the dorsal and ventral hippocampus. Neuropeptides 42 411 PMID: 18508119

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关键词: (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin, (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin supplier, Selective, vasopressin, V1A, antagonists, V2, Receptors, Vasopressin, 3377, Tocris Bioscience

1 篇 (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (d(CH₂)₅¹,Tyr(Me)²,Arg⁸)-Vasopressin 的部分引用包括：

Campos-Lira et al (2019) Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors. Front Neurosci 12 919 PMID: 30618551

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