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Submit ReviewD-CPP-ene
说明： Potent competitive NMDA antagonist
别名： Midafotel,SDZ EAA 494
化学名： D-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
生物活性 for D-CPP-ene
D-CPP-ene is a potent and competitive NMDA antagonist (Ki = 40 nM). Centrally active following systemic administration.
技术数据 for D-CPP-ene
| 分子量 | 250.19 |
| 公式 | C8H15N2O5P |
| 储存 | Desiccate at RT |
| CAS Number | 117414-74-1 |
| PubChem ID | 6435801 |
| InChI Key | VZXMZMJSGLFKQI-ABVWVHJUSA-N |
| Smiles | O=P(/C=C/CN1C[C@H]([C@](O)=O)NCC1)(O)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for D-CPP-ene
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25 | 100 |
制备储备液 for D-CPP-ene
以下数据基于产品分子量 250.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4 mL | 19.98 mL | 39.97 mL |
| 5 mM | 0.8 mL | 4 mL | 7.99 mL |
| 10 mM | 0.4 mL | 2 mL | 4 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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产品说明书 for D-CPP-ene
参考文献 for D-CPP-ene
参考文献是支持产品生物活性的出版物。
Lowe et al (1990) D-CPP-ene (SDZ EAA 494), a potent and competitive N-MthD.-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci.Lett. 113 315 PMID: 2166255
Potschka et al (1999) Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of DA and DA and serotonin metabolites in striatum of kindled and non-kindled rats. Eur.J.Pharmacol. 374 175 PMID: 10422758
Aebischer et al (1989) Synthesis and NMDA antagonistic properties of the enantiomers of 4-(3-phosphonopropyl)piperazine-2-carboxylic acid (CPP) and of the unsaturated analogue (E)-4-(3-phosphono-2-enyl)piperazine-2-carboxylic acid (CPP-ene). Helv.Chim.Acta 72 1043
If you know of a relevant reference for D-CPP-ene, please let us know.
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关键词: D-CPP-ene, D-CPP-ene supplier, Potent, competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, SDZEAA494, Midafotel, SDZ, EAA, 494, 1265, Tocris Bioscience
2 篇 D-CPP-ene 的引用文献
引用文献是使用了 Tocris 产品的出版物。 D-CPP-ene 的部分引用包括：
Campos and Ritter (2015) NMDA-type glutamate receptors participate in reduction of food intake following hindbrain melanocortin receptor activation. Oncogene 308 R1 PMID: 25394828
Cheng et al (2018) ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations. Proc Natl Acad Sci U S A 115 E292 PMID: 29279380
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