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Submit Review[D-Lys3]-GHRP-6
说明： Ghrelin receptor antagonist
纯度： ≥95% (HPLC)
生物活性 for [D-Lys3]-GHRP-6
[D-Lys3]-GHRP-6 is an antagonist at the ghrelin receptor (GHS-R1a) (IC50 = 0.9 μM). Also weakly binds to melanocortin receptors (Ki = 26-120 μM). Centrally active in vivo.
技术数据 for [D-Lys3]-GHRP-6
| 分子量 | 930.12 |
| 公式 | C49H63N13O6 |
| 序列 |
HWKWFK (Modifications: Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe, Lys-6 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 136054-22-3 |
| PubChem ID | 5311279 |
| InChI Key | MGSNWNLPMHXGDD-DFWOJPNQSA-N |
| Smiles | [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for [D-Lys3]-GHRP-6
| 溶解性 | Soluble to 0.50 mg/ml in water |
产品说明书 for [D-Lys3]-GHRP-6
参考文献 for [D-Lys3]-GHRP-6
参考文献是支持产品生物活性的出版物。
Pinilla et al (2003) Role of ghrelin in the control of GH secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77 83 PMID: 12624529
Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823
Traebert et al (2002) Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J.Neuroendocrinol. 14 580 PMID: 12121496
If you know of a relevant reference for [D-Lys3]-GHRP-6, please let us know.
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关键词: [D-Lys3]-GHRP-6, [D-Lys3]-GHRP-6 supplier, Ghrelin, receptors, antagonists, GHS-R1a, Growth, Hormone, Secretagog, 1a, Receptors, 1922, Tocris Bioscience
6 篇 [D-Lys3]-GHRP-6 的引用文献
引用文献是使用了 Tocris 产品的出版物。 [D-Lys3]-GHRP-6 的部分引用包括：
Kamei et al (2017) Rikkunshito prevents PacT.-induced peripheral neuropathy through the suppression of the nuclear factor kappa B (NFκB) phosphorylation in spinal cord of mice. PLoS One 12 e0171819 PMID: 28182729
Song et al (2013) Ghrelin modulates lateral amygdala neuronal firing and blocks acquisition for conditioned taste aversion. PLoS One 8 e65422 PMID: 23762368
Gomez and (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res 38 2436 PMID: 25257292
Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. PLoS Comput Biol 57 633 PMID: 21220707
Murtuza and Isokawa (2018) Endogenous ghrelin-O-acyltransferase (GOAT) acylates local ghrelin in the hippocampus. J Neurochem 144 58 PMID: 29063591
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One 12 e0184261 PMID: 28877214
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