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Submit Review[D-Trp8]-γ-MSH
说明： Selective MC3 receptor agonist
生物活性 for [D-Trp8]-γ-MSH
[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
技术数据 for [D-Trp8]-γ-MSH
| 分子量 | 1570.79 |
| 公式 | C74H99N21O16S |
| 序列 |
YVMGHFRWDRFG (Modifications: Trp-8 = D-Trp) |
| 储存 | Store at -20°C |
| CAS Number | 321351-81-9 |
| PubChem ID | 16157270 |
| InChI Key | GZWUQPQBOGLSIM-MDMVXOTPSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for [D-Trp8]-γ-MSH
参考文献 for [D-Trp8]-γ-MSH
参考文献是支持产品生物活性的出版物。
Grieco et al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998 PMID: 11150170
Getting et al (2006) [D-Trp8]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850 PMID: 16959942
Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835 PMID: 20702773
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关键词: [D-Trp8]-gamma-MSH, [D-Trp8]-gamma-MSH supplier, melanocortin, 3, receptors, MC3R, agonists, MC3, MC5, MC4, [D-Trp8]-gamma-MSH, [D-Trp8]-g-MSH, [D-Trp8]-γ-MSH, Melanocortin, Receptors, 4272, Tocris Bioscience
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