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Submit ReviewDaminozide
说明： Selective KDM2/7 inhibitor
化学名： 1-(2,2-Dimethylhydrazide)butanedioic acid
生物活性 for Daminozide
Daminozide is a histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.55, 1.5 and 2.1 μM for PHF8, KDM2A and KDM7A respectively). Exhibits ≥ 60-fold selectivity for KDM2/7 demethylases over other histone demethylases and 2-oxoglurate oxygenases (IC50 > 100 μM).
技术数据 for Daminozide
| 分子量 | 160.17 |
| 公式 | C6H12N2O3 |
| 储存 | Store at RT |
| CAS Number | 1596-84-5 |
| PubChem ID | 15331 |
| InChI Key | NOQGZXFMHARMLW-UHFFFAOYSA-N |
| Smiles | O=C(NN(C)C)CCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Daminozide
参考文献 for Daminozide
参考文献是支持产品生物活性的出版物。
Rose et al (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J.Med.Chem. 55 6639 PMID: 22724510
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关键词: Daminozide, Daminozide supplier, jmjc, kdm2/7, kdm2a, kdm7a, phf8, histone, demethylases, inhibits, inhibitors, selective, epigenetics, Histone, Demethylases, 4684, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Daminozide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.