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Dapansutrile

Cat. No. 6902 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NLRP3 inflammasome inhibitor; disrupts inflammasome formation
化学名： 3-(Methylsulfonyl)propanenitrile
纯度： ≥98%
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Dapansutrile

Dapansutrile is a NLRP3 inflammasome inhibitor that disrupts inflammasome formation. Reduces LPS/ATP-induced IL-1β secretion in human and mouse macrophages in vitro, without affecting TNFα levels. Reduces LPS-induced inflammation in vivo. Also reduces joint swelling and markers of inflammation in synovial fluid in a mouse model of acute arthritis. Displays cardioprotective effects in a mouse model of cardiac ischemic reperfusion injury.

OLT1177® is a registered trademark of Olatec Therapeutics LLC in the United States and other countries.

化合物库 for Dapansutrile

Dapansutrile is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Dapansutrile

分子量 133.17
公式 C4H7NO2S
储存 Store at -20°C
纯度 ≥98%
CAS Number 54863-37-5
PubChem ID 12714644
InChI Key LQFRYKBDZNPJSW-UHFFFAOYSA-N
Smiles C[S](=O)(=O)CCC#N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dapansutrile

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 13.32 100
ethanol 2.66 20

制备储备液 for Dapansutrile

以下数据基于产品分子量 133.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 7.51 mL 37.55 mL 75.09 mL
5 mM 1.5 mL 7.51 mL 15.02 mL
10 mM 0.75 mL 3.75 mL 7.51 mL
50 mM 0.15 mL 0.75 mL 1.5 mL

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参考文献 for Dapansutrile

参考文献是支持产品生物活性的出版物。

Marchetti et al (2018) OLT1177®, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc.Natl.Acad.Sci.USA. 115 E1530 PMID: 29378952

Marchetti et al (2018) NLRP3 inflammasome inhibitor OLT1177® suppresses joint inflammation in murine models of acute arthritis. Arthritis Res.Ther. 20 169 PMID: 30075804

Toldo et al (2019) The NLRP3 inflammasome inhibitor, OLT1177® (Dapansutrile), reduces infarct size and preserves contractile function after ischemia reperfusion injury in the mouse. J.Cardiovasc.Pharmacol. 73 215 PMID: 30747785

If you know of a relevant reference for Dapansutrile, please let us know.

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关键词: Dapansutrile, Dapansutrile supplier, dapansutrile, NLRP3, inflammasome, inhibitors, inhibits, cardioprotective, arthritis, reperfusion, anti, inflammatory, Inflammasomes, 6902, Tocris Bioscience

1 篇 Dapansutrile 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dapansutrile 的部分引用包括：

Michelle K et al (2023) Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19. iScience 26 106929 PMID: 37260746

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