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说明： Chemokine receptor 5 (CCR5) antagonist
别名： D-Ala-peptide T-amide
生物活性 for DAPTA
DAPTA is a chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.
技术数据 for DAPTA
| 分子量 | 856.89 |
| 公式 | C35H56N10O15 |
| 序列 |
ASTTTNYT (Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 106362-34-9 |
| PubChem ID | 184644 |
| InChI Key | AKWRNBWMGFUAMF-ZESMOPTKSA-N |
| Smiles | [H]N[C@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DAPTA
参考文献 for DAPTA
参考文献是支持产品生物活性的出版物。
Ruff et al (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 1 51 PMID: 15043212
Rosi et al (2005) Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134 671 PMID: 15979806
Polianova et al (2005) Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67 83 PMID: 16002156
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关键词: DAPTA, DAPTA supplier, Chemokine, receptor, 5, CCR5, antagonists, CXCR, Receptors, antiviral, Rantes, D-Ala-peptide, T-amide, CC, HIV, 2423, Tocris Bioscience
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