Daunorubicin hydrochloride

Name: Daunorubicin hydrochloride
Brand: Tocris Bioscience
SKU: 1467
Rating: 5 (1 reviews)

Cat. No. 1467 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： DNA topoisomerase II inhibitor

别名： Daunomycin

化学名： (8S,10S)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyransoyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Daunorubicin hydrochloride

Daunorubicin hydrochloride is a DNA topoisomerase II inhibitor. Inhibits RNA and DNA synthesis and causes DNA fragmentation in vivo. Reduces tau mRNA levels in vitro.Anticancer agent. Exhibits activity against nonlymphocytic leukemia. Identified as targeting human host proteins that interact with SARS-CoV-2. Also enhances adeno-associated virus transduction of HeLa cells in vitro.

技术数据 for Daunorubicin hydrochloride

分子量	563.99
公式	C₂₇H₂₉NO₁₀.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	23541-50-6
PubChem ID	3085106
InChI Key	GUGHGUXZJWAIAS-CFCXLQPVSA-N
Smiles	NC1CC(O[C@H]2C[C@@]([C@@](C)=O)(O)CC3=C2C(O)=C5C(C(C4=CC=CC(OC)=C4C5=O)=O)=C3O)OC(C)C1O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Daunorubicin hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		50

制备储备液 for Daunorubicin hydrochloride

以下数据基于产品分子量 563.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	3.55 mL	17.73 mL	35.46 mL
2.5 mM	0.71 mL	3.55 mL	7.09 mL
5 mM	0.35 mL	1.77 mL	3.55 mL
25 mM	0.07 mL	0.35 mL	0.71 mL

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产品说明书 for Daunorubicin hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Daunorubicin hydrochloride

参考文献是支持产品生物活性的出版物。

Aubel-Sadron and Londos-Gagliardi (1984) Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review. Biochimie 66 333 PMID: 6380596

Gewirtz (1999) A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunoru. Biochem.Pharmacol. 57 727 PMID: 10075079

Laurent and Jaffrezou (2001) Signaling pathways activated by daunoru. Blood 98 913 PMID: 11493433

Dickey et al (2006) Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol.Neurodegen. 1 6 PMID: 16930453

Nicolson et al (2016) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 90 7019 PMID: 27147738

Gordon et al (2020) A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing. Nature 583 PMID: 32353859

Pommier et al (2010) DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem.Biol. 17 421 PMID: 20534341

If you know of a relevant reference for Daunorubicin hydrochloride, please let us know.

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⚠ WARNING: This product can expose you to chemicals including Daunorubicin hydrochloride, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

3 篇 Daunorubicin hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Daunorubicin hydrochloride 的部分引用包括：

Chhablani et al (2013) Oxidized porous silicon particles covalently grafted with daunoru. as a sustained intraocular drug delivery system. Invest Ophthalmol Vis Sci 54 1268 PMID: 23322571

Jones et al (2013) An alternative direct compound dispensing method using the HP D300 digital dispenser. PLoS One 18 367 PMID: 23708834

Zhao and Zhang (2017) Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. Sci Rep 7 44735 PMID: 28300219

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Mechanism of action of Daunorubicin hydrochloride was studied.

By Anonymous on 12/26/2019

种属： Human

Mechanism of action of Daunorubicin hydrochloride was studied in order to understand the inhibition of the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.