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Discontinued Product
7907 has been discontinued.
View all Post-translational Modifications products.
说明： Potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2
纯度： ≥95% (HPLC)
生物活性 for DC 432
DC 432 is a potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) (IC50 = 54 nM). Comprises a BM30 peptide with five additional arginine residues. DC 432 treatment in HCT116 cells decreases the N-terminal methylation level of the regulator of chromosome condensation 1 and SET proteins. Cell permeable.
技术数据 for DC 432
| 分子量 | 1313.59 |
| 公式 | C55H100N28O10 |
| 序列 |
PKRRRRRR (Modifications:Pro-1 = 4-Hydroxyphenylacetyl-Pro; C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2388988-70-1 |
| InChI Key | UVDZRYDWESJRQX-ZHECQJHESA-N |
| Smiles | O=C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)[C@@H]1N(C(CC2=CC=C(O)C=C2)=O)CCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DC 432
参考文献 for DC 432
参考文献是支持产品生物活性的出版物。
Mackie et al (2020) Selective peptidomimetic inhibitors of NTMT1/2: rational design, synthesis, characterization, and crystallographic studies. J.Med.Chem. 63 9512 PMID: 32689795
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关键词: DC 432, DC 432 supplier, DC432, BM30, potent, peptidomimetic, Inhibitors, Inhibition, inhibits, N-terminal, methyltransferase1/2, NTMT1/2, Post-translational, Modifications, Mitosis, 7907, Tocris Bioscience
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