DCEBIO

Cat. No. 1422 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Activates Cl- conductance and hKCa3.1 channels

化学名： 5,6-Dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

纯度： ≥99% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DCEBIO

DCEBIO is a stimulates Cl^- secretion via the activation of hK_Ca3.1 (IK1) potassium channels and an apical Cl^- conductance carried by the CFTR channel. More potent than its analog 1-EBIO (Cat. No. 1041).

化合物库 for DCEBIO

DCEBIO is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for DCEBIO

分子量	231.08
公式	C₉H₈Cl₂N₂O
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	60563-36-2
PubChem ID	656765
InChI Key	LKHRMULASXZCLG-UHFFFAOYSA-N
Smiles	CCN1C(=O)NC2=C1C=C(Cl)C(Cl)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DCEBIO

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	23.11	100
	ethanol	23.11	100

制备储备液 for DCEBIO

以下数据基于产品分子量 231.08。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.33 mL	21.64 mL	43.28 mL
5 mM	0.87 mL	4.33 mL	8.66 mL
10 mM	0.43 mL	2.16 mL	4.33 mL
50 mM	0.09 mL	0.43 mL	0.87 mL

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产品说明书 for DCEBIO

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DCEBIO

参考文献是支持产品生物活性的出版物。

Singh et al (2001) Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J.Pharmacol.Exp.Ther. 296 600 PMID: 11160649

Hamilton and Kiessling et al (2006) DCEBIO stimulates Cl- secretion in the mouse jejunum. Am.J.Physiol.Cell Physiol. 290 152 PMID: 16135545

If you know of a relevant reference for DCEBIO, please let us know.

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关键词: DCEBIO, DCEBIO supplier, potent, Activators, hIK1/Cl-, conductance, K+, channels, Potassium, KCa, KCa3.1, Channels, ca2+-activated, ca2+-dependent, Chloride, Ca2+-Activated, CFTR, 1422, Tocris Bioscience