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Submit Reviewd[Cha4]-AVP
说明： Potent and selective human V1B agonist
生物活性 for d[Cha4]-AVP
d[Cha4]-AVP is a potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
技术数据 for d[Cha4]-AVP
| 分子量 | 1094.31 |
| 公式 | C50H71N13O11S2 |
| 序列 |
XYFXNCPRG (Modifications: X-1 = Mpr, X-4 = Cha, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6) |
| 储存 | Store at -20°C |
| CAS Number | 500170-27-4 |
| PubChem ID | 44419028 |
| InChI Key | ZKYCVZNKBXGNEK-ZTYVOHGWSA-N |
| Smiles | NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for d[Cha4]-AVP
参考文献 for d[Cha4]-AVP
参考文献是支持产品生物活性的出版物。
Derick et al (2002) [1-Deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology 143 4655 PMID: 12446593
Cheng et al (2004) Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J.Med.Chem. 47 2375 PMID: 15084136
Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835 PMID: 17300166
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关键词: d[Cha4]-AVP, d[Cha4]-AVP supplier, Potent, selective, human, V1b, agonists, V2, Receptors, Vasopressin, 3126, Tocris Bioscience
1 篇 d[Cha4]-AVP 的引用文献
引用文献是使用了 Tocris 产品的出版物。 d[Cha4]-AVP 的部分引用包括：
Perígolo-Vicente et al (2014) IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun 449 477 PMID: 24845382
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.