DEL 22379

Cat. No. 5774 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： ERK dimerization inhibitor

化学名： N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for DEL 22379

DEL 22379 is an ERK dimerization inhibitor (IC₅₀ ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.

技术数据 for DEL 22379

分子量	444.53
公式	C₂₆H₂₈N₄O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	181223-80-3
PubChem ID	11224574
InChI Key	INQUULPXCZAKMS-XKZIYDEJSA-N
Smiles	O=C1NC2=CC=C(NC(CCN3CCCCC3)=O)C=C2/C1=C/C4=CNC5=C4C=C(OC)C=C5

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DEL 22379

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	22.23	50

制备储备液 for DEL 22379

以下数据基于产品分子量 444.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.5 mL	22.5 mL	44.99 mL
2.5 mM	0.9 mL	4.5 mL	9 mL
5 mM	0.45 mL	2.25 mL	4.5 mL
25 mM	0.09 mL	0.45 mL	0.9 mL

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产品说明书 for DEL 22379

分析证书/产品说明书

化学品安全技术说明书

参考文献 for DEL 22379

参考文献是支持产品生物活性的出版物。

Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170 PMID: 26267534

Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183 PMID: 26858988

If you know of a relevant reference for DEL 22379, please let us know.

按标靶查看相关产品

关键词: DEL 22379, DEL 22379 supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, 5774, Tocris Bioscience

1 篇 DEL 22379 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DEL 22379 的部分引用包括：

Saranya Santhosh et al (2019) The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. Cell 179 1306-1318.e18 PMID: 31761535

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for DEL 22379

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.