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Submit ReviewDEL 22379
说明： ERK dimerization inhibitor
化学名： N-[2,3-Dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2-oxo-1H-indol-5-yl]-1-piperidinepropanamide
纯度： ≥98% (HPLC)
生物活性 for DEL 22379
DEL 22379 is an ERK dimerization inhibitor (IC50 ~ 0.5 μM); inhibits ERK dimerization without affecting phosphorylation or kinase activity. Suppresses growth of tumor cells expressing RAS-ERK oncogenes in vitro. Induces apoptosis and prevents tumor progression in vivo.
技术数据 for DEL 22379
| 分子量 | 444.53 |
| 公式 | C26H28N4O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 181223-80-3 |
| PubChem ID | 11224574 |
| InChI Key | INQUULPXCZAKMS-XKZIYDEJSA-N |
| Smiles | O=C1NC2=CC=C(NC(CCN3CCCCC3)=O)C=C2/C1=C/C4=CNC5=C4C=C(OC)C=C5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for DEL 22379
参考文献 for DEL 22379
参考文献是支持产品生物活性的出版物。
Herrero et al (2015) Small molecule inhibition of ERK dimerization prevents tumorigenesis by RAS-ERK pathway oncogenes. Cancer Cell 28 170 PMID: 26267534
Ryan et al (2015) Targeting RAS-mutant cancers: is ERK the key? Trends Cancer 1 183 PMID: 26858988
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关键词: DEL 22379, DEL 22379 supplier, ERK, dimerization, inhibitors, inhibits, extracellular, signal, related, kinase, RAS, 5774, Tocris Bioscience
1 篇 DEL 22379 的引用文献
引用文献是使用了 Tocris 产品的出版物。 DEL 22379 的部分引用包括：
Saranya Santhosh et al (2019) The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER. Cell 179 1306-1318.e18 PMID: 31761535
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
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