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ERK

Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels.

Products
Background
Literature (1)
Pathways (1)
Gene Data

ERK Inhibitors
Cat. No. Product Name / Activity
5843 AX 15836
Potent and selective ERK5 inhibitor
4842 BIX 02189
Selective MEK5 and ERK5 inhibitor
5393 ERK5-IN-1
Potent and selective ERK5 inhibitor
3706 FR 180204
Selective ERK inhibitor
4465 TCS ERK 11e
Potent and selective ERK2 inhibitor
4132 XMD 8-92
ERK5/BMK1 inhibitor; also BRD4 inhibitor
1036 ZM 241385
Inhibits ERK pathway

Other
Cat. No. Product Name / Activity
7713 AMG 510
Potent pERK inhibitor; KRASG12C inhibitor
5774 DEL 22379
ERK dimerization inhibitor

Related Targets

Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK.

Activation of an ERK signaling pathway often involves regulation of cell division, migration and survival; dysregulation of these pathways has been associated with various diseases, including cancer. ERK signaling has also been linked to the positive regulation of synaptic plasticity and long-term potentiation (LTP).

External sources of pharmacological information for ERK :

    Literature for ERK

    Tocris offers the following scientific literature for ERK to showcase our products. We invite you to request* your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.

    MAPK Signaling Scientific Review

    MAPK Signaling Scientific Review

    MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

    Pathways for ERK

    MAPK Signaling Pathway

    MAPK Signaling Pathway

    The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

    ERK Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ERK1 Human MAPK3 NM_001040056 P27361
    Mouse Mapk3 NM_011952 Q63844
    Rat Mapk3 NM_017347 P21708
    ERK2 Human MAPK1 NM_138957 P28482
    Mouse Mapk1 NM_011949 P63085
    Rat Mapk1 NM_053842 P63086
    ERK3 Human MAPK6 NM_002748 Q16659
    Mouse Mapk6 NM_027418 Q61532
    Rat Mapk6 NM_031622 P27704
    ERK4 Human MAPK4 NM_002747 P31152
    Mouse Mapk4 NM_172632 Q6P5G0
    Rat Mapk4 NM_031622 P27704
    ERK5 Human MAPK7 NM_002749 Q13164
    Mouse Mapk7 NM_011841 Q9WVS8
    Rat Mapk7 AJ005424 O89037
    ERK7/8 Human MAPK15 NM_139021 Q8TD08
    Mouse Mapk15 NM_177922 Q80Y86
    Rat Mapk15 NM_173331 Q9Z2A6