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Demethylasterriquinone B1

Cat. No. 1819 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective insulin RTK activator
别名： DAQ B1,L-783,281,DMAQ-B1
化学名： 2-[2-(1,1-Dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1H-indol-3-yl]-2,5-cyclohexadiene-1,4-dione
纯度： ≥95% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Demethylasterriquinone B1

Demethylasterriquinone B1 is a selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.

技术数据 for Demethylasterriquinone B1

分子量 506.59
公式 C32H30N2O4
储存 Desiccate at -20°C
纯度 ≥95% (HPLC)
CAS Number 78860-34-1
PubChem ID 3013166
InChI Key XMGNJVXBPZAETK-UHFFFAOYSA-N
Smiles CC(C)=CCC1=C2NC=C(C2=CC=C1)C1=C(O)C(=O)C(C2=C(NC3=CC=CC=C23)C(C)(C)C=C)=C(O)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Demethylasterriquinone B1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 50.66 100

制备储备液 for Demethylasterriquinone B1

以下数据基于产品分子量 506.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

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产品说明书 for Demethylasterriquinone B1

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Demethylasterriquinone B1

参考文献是支持产品生物活性的出版物。

Kim et al (2007) Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the Ins mimic demethylasterriquinone B1. J.Med.Chem. 50 3423 PMID: 17595071

Salituro et al (2001) Discovery of a small molecule Ins receptor activator. Recent Prog.Horm.Res. 56 107 PMID: 11237209

Weber et al (2000) A novel Ins mimetic without a proliferative effect on vascular smooth muscle cells. J.Vasc.Surg. 32 1118 PMID: 11107083

Webster et al (2003) Signaling effects of demethylasterriquinone B1, a selective Ins receptor modulator. Chembiochem 4 379 PMID: 12740809

Wilkie et al (2001) The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. J.Neurochem. 78 1135 PMID: 11553687

If you know of a relevant reference for Demethylasterriquinone B1, please let us know.

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关键词: Demethylasterriquinone B1, Demethylasterriquinone B1 supplier, Selective, insulin, IRs, RTKs, activators, IGF, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, DemethylasterriquinoneB1, DAQB1, L783281, DAQ, B1, L-783,281, DMAQ-B1, Insulin, and, insulin-like, Trk, 1819, Tocris Bioscience

1 篇 Demethylasterriquinone B1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Demethylasterriquinone B1 的部分引用包括：

Pitt et al (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell 28 2623 PMID: 28963439

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Demethylasterriquinone B1 的评论

平均评分: 4 (Based on 1 Review.)

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works well.
By Anonymous on 03/26/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Hippocampal neuron

10 μM

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