des-His¹-[Glu⁹]-Glucagon (1-29) amide

Cat. No. 2216 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Glucagon receptor antagonist

纯度： ≥95% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for des-His¹-[Glu⁹]-Glucagon (1-29) amide

des-His¹-[Glu⁹]-Glucagon (1-29) amide is a glucagon receptor antagonist (pA₂ = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hyperglycemia in normal rabbits without affecting glycogenolysis in vivo. Also blocks endogenous glucagon-induced hyperglycemia in streptozocin diabetic rats.

技术数据 for des-His¹-[Glu⁹]-Glucagon (1-29) amide

分子量	3358.68
公式	C₁₄₈H₂₂₁N₄₁O₄₇S
序列	SQGTFTSEYSKYLDSRRAQDFVQWLMNT (Modifications: Thr-28 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	110084-95-2
PubChem ID	16133829
InChI Key	RVXSASLSNHDASC-OSWDIKPLSA-N
Smiles	[H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for des-His¹-[Glu⁹]-Glucagon (1-29) amide

溶解性	Soluble to 1 mg/ml in water

产品说明书 for des-His¹-[Glu⁹]-Glucagon (1-29) amide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for des-His¹-[Glu⁹]-Glucagon (1-29) amide

参考文献是支持产品生物活性的出版物。

Unson et al (1989) Biological activities of des-His¹[Glu⁹]glucagon amide, a glucagon antagonist. Peptides 10 1171 PMID: 2560175

Huypens et al (2000) Glucagon receptors on human islet cells contribute to glucose competence of Ins release. Diabetologia 43 1012 PMID: 10990079

Unson et al (1987) Synthetic peptide antagonists of glucagon. Proc.Natl.Acad.Sci.USA 84 4083

If you know of a relevant reference for des-His¹-[Glu⁹]-Glucagon (1-29) amide, please let us know.

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关键词: des-His1-[Glu9)-Glucagon (1-29) amide, des-His1-[Glu9)-Glucagon (1-29) amide supplier, Glucagon, receptor, antagonists, antagonist, receptors, Receptor, 2216, Tocris Bioscience

1 篇 des-His¹-[Glu⁹]-Glucagon (1-29) amide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 des-His¹-[Glu⁹]-Glucagon (1-29) amide 的部分引用包括：

Weston et al (2015) Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2). Acta Pharmacol Sin 290 23009 PMID: 26198634

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