Glucagon Receptors

The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels and is predominantly expressed in the pancreas, liver and kidneys.

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Background
文献 (1)
Gene Data

Glucagon Receptor Agonists

Cat. No. 产品名称/活性
6927 Glucagon (Human, Porcine)
Endogenous glucagon receptor agonist

Glucagon Receptor Antagonists

Cat. No. 产品名称/活性
2216 des-His1-[Glu9]-Glucagon (1-29) amide
Glucagon receptor antagonist
2311 L-168,049
Potent, orally active human glucagon receptor antagonist

Glucagon Receptor Modulators

Cat. No. 产品名称/活性
6807 NNC 0640
Negative allosteric modulator of glucagon and GLP-1 receptors

The glucagon receptor is a member of the glucagon receptor family that also includes GLP-1, GLP-2, secretin, GHRH and GIP receptors. The glucagon receptor regulates blood glucose levels via control of hepatic glycogenolysis and gluconeogenesis, and via regulation of insulin release from the β-cells of pancreatic islets.

The glucagon receptor is predominantly expressed in the pancreas, liver and kidneys, but is also found to a lesser extent in the heart, adipose tissue, spleen, thymus and adrenal glands. The human glucagon receptor gene is localized on chromosome 17q25.

External sources of pharmacological information for Glucagon Receptors :

Literature for Glucagon Receptors

Tocris offers the following scientific literature for Glucagon Receptors to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Glucagon Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human GCGR NM_000160 P47871
Mouse Gcgr NM_008101 Q61606
Rat Gcgr NM_172091 P30082