[Des-octanoyl]-Ghrelin (human)

Name: [Des-octanoyl]-Ghrelin (human)
Brand: Tocris Bioscience
SKU: 2260

Cat. No. 2260 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2260 has been discontinued.

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说明： Major circulating form of ghrelin; devoid of activity at ghrelin receptor but is active in vivo

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for [Des-octanoyl]-Ghrelin (human)

[Des-octanoyl]-Ghrelin (human) is a non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release. However, exerts negative inotropic effects in papillary muscle and displays cardioprotective activity. Inhibits cell proliferation in breast and prostate cancer cell lines. Promotes adipogenesis in vivo.

技术数据 for [Des-octanoyl]-Ghrelin (human)

分子量	3244.51
公式	C₁₄₁H₂₃₅N₄₇O₄₁
序列	GSSFLSPEHQRVQQRKESKKPPAKLQPR
储存	Desiccate at -20°C
CAS Number	313951-59-6
PubChem ID	46236457
InChI Key	BGHSOEHUOOAYMY-JTZMCQEISA-N
Smiles	[H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for [Des-octanoyl]-Ghrelin (human)

分析证书/产品说明书

化学品安全技术说明书

参考文献 for [Des-octanoyl]-Ghrelin (human)

参考文献是支持产品生物活性的出版物。

Baldanzi et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J.Cell Biol. 159 1029 PMID: 12486113

Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln¹⁴-ghrelin. Eur.J.Pharmacol. 476 87 PMID: 12969753

Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor. Endocrinology 145 234 PMID: 14551228

Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173 PMID: 14763915

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关键词: [Des-Octanoyl]-Ghrelin (human), [Des-Octanoyl]-Ghrelin (human) supplier, circulating, ghrelin, devoid, activity, receptors, active, in, vivo, GHS-R1a, Growth, Hormone, Secretagog, 1a, Ghrelin, Receptors, 2260, Tocris Bioscience

1 篇 [Des-octanoyl]-Ghrelin (human) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 [Des-octanoyl]-Ghrelin (human) 的部分引用包括：

Rodríguez et al (2009) Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. FASEB J 33 541 PMID: 19238155