[Des-octanoyl]-Ghrelin (rat)

Discontinued Product

2951 has been discontinued.

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说明: Major circulating form of ghrelin; devoid of activity at GHS receptor
别名: Des-acyl ghrelin (rat)
纯度: ≥95% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)

生物活性 for [Des-octanoyl]-Ghrelin (rat)

[Des-octanoyl]-Ghrelin (rat) is a non-acylated, major circulating isoform of ghrelin that does not bind to the ghrelin receptor (GHS-R1a), nor induce growth hormone release.

技术数据 for [Des-octanoyl]-Ghrelin (rat)

分子量 3188.63
公式 C139H231N45O41
序列 GSSFLSPEHQKAQQRKESKKPPAKLQPR
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 307950-60-3
PubChem ID 90488789
InChI Key CMCPTGQGZXKKEH-MGXJLMSJSA-N
Smiles [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for [Des-octanoyl]-Ghrelin (rat)

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参考文献 for [Des-octanoyl]-Ghrelin (rat)

参考文献是支持产品生物活性的出版物。

Bedendi et al (2003) Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin. Eur.J.Pharmacol. 476 87 PMID: 12969753

Thompson et al (2004) Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a GH secretagogue receptor Endocrinology 145 234 PMID: 14551228

Cassoni et al (2004) Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines. Eur.J.Endocrinol. 150 173 PMID: 14763915

关键词: [des-octanoyl]-Ghrelin (rat), [des-octanoyl]-Ghrelin (rat) supplier, circulating, ghrelin, devoid, activity, GHS-R1a, Receptors, Growth, Hormone, Secretagogue, Receptor, 1a, Ghrelin, Des-acyl, (rat), 2951, Tocris Bioscience

2 篇 [Des-octanoyl]-Ghrelin (rat) 的引用文献

引用文献是使用了 Tocris 产品的出版物。 [Des-octanoyl]-Ghrelin (rat) 的部分引用包括:

Engel et al (2015) Blockade of GH secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl) 232 4285 PMID: 26319159

Kemp et al (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. Br J Pharmacol 57 633 PMID: 21220707


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