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Submit ReviewDesmopressin
说明： Synthetic vasopressin analog; V1B and V2 agonist
纯度： ≥95% (HPLC)
生物活性 for Desmopressin
Desmopressin is a synthetic vasopressin analog that acts as an agonist at V1B and V2 receptors (EC50 values are 11.4 and 23.9 nM and Ki values are 5.84 and 65.9 nM respectively). Prevents polycystic kidney disease formation and exhibits antidiuretic, antiproliferative, hemostatic and hypotensive activity in vivo.
技术数据 for Desmopressin
| 分子量 | 1069.22 |
| 公式 | C46H64N14O12S2 |
| 序列 |
XYFQNCPRG (Modifications: X = Mpr, Arg-8 = D-Arg, Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 16679-58-6 |
| PubChem ID | 5311065 |
| InChI Key | NFLWUMRGJYTJIN-PNIOQBSNSA-N |
| Smiles | NC(=O)CC[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Desmopressin
| 溶解性 | Soluble to 4 mg/ml in water |
产品说明书 for Desmopressin
参考文献 for Desmopressin
参考文献是支持产品生物活性的出版物。
Saito et al (1997) 1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V1b vasopressin receptor. Biochem.Pharmacol. 53 1711 PMID: 9264324
Gomez et al (2006) Desmopressin and other synthetic vasopressin analogues in cancer treatment. Bull.Cancer 93 E7 PMID: 16517412
Torres (2008) Vasopressin antagonists in polycystic kidney disease. Semin.Nephrol. 28 306 PMID: 18519091
If you know of a relevant reference for Desmopressin, please let us know.
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关键词: Desmopressin, Desmopressin supplier, Synthetic, vasopressin, analog, V1B, V2, agonists, Receptors, Vasopressin, 3396, Tocris Bioscience
1 篇 Desmopressin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Desmopressin 的部分引用包括：
Campos-Lira et al (2019) Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors. Front Neurosci 12 919 PMID: 30618551
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.