Dexfenfluramine hydrochloride

Cat. No. 2695 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： 5-HT reuptake inhibitor; also stimulates 5-HT release

别名： (+)-Fenfluramine

化学名： (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride

纯度： ≥95% (HPLC)

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Dexfenfluramine hydrochloride

Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.

技术数据 for Dexfenfluramine hydrochloride

分子量	267.72
公式	C₁₂H₁₆F₃N.HCl
储存	Desiccate at RT
纯度	≥95% (HPLC)
CAS Number	3239-45-0
PubChem ID	66264
InChI Key	ZXKXJHAOUFHNAS-FVGYRXGTSA-N
Smiles	C[C@H](NCC)CC1=CC=CC(C(F)(F)F)=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dexfenfluramine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	26.77	100
	DMSO	26.77	100

制备储备液 for Dexfenfluramine hydrochloride

以下数据基于产品分子量 267.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.74 mL	18.68 mL	37.35 mL
5 mM	0.75 mL	3.74 mL	7.47 mL
10 mM	0.37 mL	1.87 mL	3.74 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

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产品说明书 for Dexfenfluramine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Dexfenfluramine hydrochloride

参考文献是支持产品生物活性的出版物。

Caccia et al (1997) Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluox. Pharmacol.Biochem.Behav. 57 851 PMID: 9259015

Higgins et al (2001) Influence of the 5-HT_2C receptor antagonist SB242,084 on behaviour produced by the 5-HT₂ agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. Br.J.Pharmacol. 133 459 PMID: 11399662

Bush et al (2006) Chronic treatment with either dexfenfluramine or sibutr. in diet-switched diet-induced obese mice. Endocrine 29 375 PMID: 16785615

If you know of a relevant reference for Dexfenfluramine hydrochloride, please let us know.

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关键词: Dexfenfluramine hydrochloride, Dexfenfluramine hydrochloride supplier, 5-HT, reuptake, inhibitors, inhibits, stimulates, release, Serotonin, 5-Hydroxytryptamine, Receptors, Transporters, SERT, Monoamine, Neurotransmitter, (+)-Fenfluramine, 5-HT-Related, 5-HT3, 2695, Tocris Bioscience

4 篇 Dexfenfluramine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Dexfenfluramine hydrochloride 的部分引用包括：

Kiyasova et al (2011) A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. J Neurosci 31 2756 PMID: 21414898

Banas et al (2011) Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology 36 423 PMID: 20927048

Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392 PMID: 27413150

Rodríguez-Muñoz et al (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget 9 23373 PMID: 29805740

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