5-HT3 Receptors
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of four transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).
5-HT3 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 0440 | m-Chlorophenylbiguanide hydrochloride |
| Potent and selective 5-HT3 agonist | |
| 6426 | PSEM 89S |
| PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | |
| 0629 | Quipazine dimaleate |
| 5-HT3 agonist | |
| 3547 | Serotonin hydrochloride |
| Endogenous 5-HT receptor agonist | |
| 1205 | SR 57227 hydrochloride |
| Potent and selective 5-HT3 agonist | |
| 6866 | uPSEM 817 tartrate |
| Highly potent and selective PSAM4-5-HT3 and PSAM4-GlyR agonist | |
5-HT3 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 2903 | Granisetron hydrochloride |
| 5-HT3 antagonist | |
| 0640 | MDL 72222 |
| 5-HT3 antagonist | |
| 2018 | Mirtazapine |
| Potent 5-HT3 antagonist; also 5-HT2, H1 and α2 antagonist; antidepressant | |
| 2891 | Ondansetron hydrochloride |
| Selective 5-HT3 antagonist | |
| 7038 | Palonosetron hydrochloride |
| Highly potent and high affinity 5-HT3 antagonist | |
| 2459 | Tropisetron hydrochloride |
| Potent 5-HT3 antagonist; also α7 nAChR partial agonist | |
| 1795 | Zacopride hydrochloride |
| Highly potent 5-HT3 antagonist; also 5-HT4 agonist | |
Other |
|
| Cat. No. | Product Name / Activity |
| 2813 | D-Amphetamine sulfate |
| Induces 5-HT, dopamine and noradrenalin release | |
| 0767 | Bifemelane hydrochloride |
| MAO-A and MAO-B inhibitor | |
| 0938 | p-Chlorophenylalanine |
| Tryptophan hydroxylase inhibitor | |
| 2695 | Dexfenfluramine hydrochloride |
| 5-HT re-uptake inhibitor. Also stimulates 5-HT release | |
| 0475 | Dihydroergotamine mesylate |
| 5-HT antagonist; also partial agonist at adrenergic and D2-like receptors | |
| 2460 | Lazabemide hydrochloride |
| Selective MAO-B inhibitor | |
| 4395 | Moclobemide |
| Reversible MAO-A inhibitor | |
| 6425 | PSEM 308 hydrochloride |
| PSAML141F,Y115F-5-HT3 chimeric ion channel agonist | |
| 4308 | Rasagiline mesylate |
| Selective, irreversible MAO-B inhibitor | |
Serotonin 5-HT3 receptors, are ligand-gated ion channels of the Cys-loop family. The receptor consists of 4-transmembrane domains that form an intrinsic cation-selective channel. So far five human 5-HT3 receptor subtypes have been identified (5-HT3A-E).
The 5-HT3B-E subtypes do not form functional homo-oligomeric complexes like the 5-HT3A subtypes, but co-assemble with 5-HT3A to influence its functional expression.
External sources of pharmacological information for 5-HT3 Receptors :
Literature for 5-HT3 Receptors
Tocris offers the following scientific literature for 5-HT3 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
5-HT3 Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| 5-HT3A | Human | HTR3A | NM_000869 | P46098 |
| Mouse | Htr3a | NM_013561 | P23979 | |
| Rat | Htr3a | NM_024394 | P35563 | |
| 5-HT3B | Human | HTR3B | NM_006028 | O95264 |
| Mouse | Htr3b | NM_020274 | Q9JHJ5 | |
| Rat | Htr3b | NM_022189 | Q9JJ16 | |
| 5-HT3C | Human | HTR3C | NM_130770 | Q8WXA8 |
| 5-HT3D | Human | HTR3D | NM_182537 | Q70Z44 |
| 5-HT3E | Human | HTR3E | NM_182589 | A5X5Y0 |
Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
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