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DFMO

Cat. No. 2761 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Ornithine decarboxylase inhibitor
别名： Eflornithine
化学名： DL-2-(Difluoromethyl)-ornithine hydrochloride
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DFMO

DFMO is an irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.

技术数据 for DFMO

分子量 218.63
公式 C6H12F2N2O2.HCl
储存 Desiccate at RT
CAS Number 68278-23-9
PubChem ID 57004
InChI Key VKDGNNYJFSHYKD-UHFFFAOYSA-N
Smiles NC(C(F)F)(C(O)=O)CCCN.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DFMO

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 16.4 75

制备储备液 for DFMO

以下数据基于产品分子量 218.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 6.1 mL 30.49 mL 60.99 mL
3.75 mM 1.22 mL 6.1 mL 12.2 mL
7.5 mM 0.61 mL 3.05 mL 6.1 mL
37.5 mM 0.12 mL 0.61 mL 1.22 mL

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产品说明书 for DFMO

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for DFMO

参考文献是支持产品生物活性的出版物。

Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353 PMID: 17371277

Carrillo et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279 663

Wu et al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693 PMID: 22132744

If you know of a relevant reference for DFMO, please let us know.

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关键词: DFMO, DFMO supplier, Ornithine, decarboxylases, inhibitors, inhibits, Eflornithine, Decarboxylases, 2761, Tocris Bioscience

1 篇 DFMO 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DFMO 的部分引用包括：

Machado et al (2021) Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation. Cell Stem Cell 28 1 PMID: 33609440

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