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DG 041

Cat. No. 6240 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective EP3 antagonist; antiplatelet and antithrombotic
化学名： (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DG 041

DG 041 is a potent and selective EP3 antagonist (IC50 = 4.6 nM). Inhibits PGE2 facilitation of platelet aggregation in vitro and ex vivo. Displays good plasma and metabolic stability. Does not affect bleeding time in rats. Antiplatelet and antithrombotic.

技术数据 for DG 041

分子量 592.32
公式 C23H15Cl4FN2O3S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 861238-35-9
PubChem ID 11296282
InChI Key BFBTVZNKWXWKNZ-HWKANZROSA-N
Smiles CC1=CN(C2=C(C=C(C=C12)F)/C=C/C(NS(=O)(C3=CC(Cl)=C(S3)Cl)=O)=O)CC4=C(C=C(C=C4)Cl)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DG 041

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 59.23 100

制备储备液 for DG 041

以下数据基于产品分子量 592.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.44 mL 16.88 mL
5 mM 0.34 mL 1.69 mL 3.38 mL
10 mM 0.17 mL 0.84 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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参考文献 for DG 041

参考文献是支持产品生物活性的出版物。

Markovič et al (2017) Structural features of subtype-selective EP receptor modulators. Drug Discov.Today. 22 57 PMID: 27506873

Singh et al (2009) Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem.Biol. 4 115 PMID: 19193156

If you know of a relevant reference for DG 041, please let us know.

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关键词: DG 041, DG 041 supplier, DG041, potent, selective, EP3, antagonists, Receptors, Prostanoid, prostaglandins, prostacyclins, eicosanoids, 6240, Tocris Bioscience

1 篇 DG 041 的引用文献

引用文献是使用了 Tocris 产品的出版物。 DG 041 的部分引用包括：

Dieter et al (2016) Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 7 32462-77 PMID: 27074574

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