主页 / 细胞生物学 / Signal Transduction / Transcription Factors / Other Transcription Factors / Other Transcription Factor Modulators / DHC-156

DHC-156

Cat. No. 8168 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Brachyury down modulator
化学名： (E)-4-(Dimethylamino)-N-[1-[4-fluoro-3-(2,2,2-trifluoroethoxy)anilino]-6-methoxy-7-isoquinolyl]but-2-enamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for DHC-156

DHC-156 is a brachyury down modulator (DC50 = 4.1 μM, DMax > 99% at 10 μM). DHC-156 down modulates brachyury post-translationally, in a proteasome- and lysosome-independent manner. DHC-156 down modulation of brachyury results in an irreversible impairment of chordoma tumor cell growth.

技术数据 for DHC-156

分子量 492.47
公式 C24H24F4N4O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
PubChem ID 171038043
InChI Key SBZOWNJIUPEINK-SNAWJCMRSA-N
Smiles COC1=C(C=C2C(NC3=CC(OCC(F)(F)F)=C(C=C3)F)=NC=CC2=C1)NC(/C=C/CN(C)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for DHC-156

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.25 100

制备储备液 for DHC-156

以下数据基于产品分子量 492.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.03 mL 10.15 mL 20.31 mL
5 mM 0.41 mL 2.03 mL 4.06 mL
10 mM 0.2 mL 1.02 mL 2.03 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for DHC-156

参考文献是支持产品生物活性的出版物。

Chase et al (2024) Development of a small molecule downmodulator for the transcription factor brachyury. Angew.Chem.Int.Ed.Engl. 63 e202316496 PMID: 38348945

If you know of a relevant reference for DHC-156, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other Transcription Factor Modulators

关键词: DHC-156, DHC-156 supplier, brachyury, down, modulator, downmodulator, modulation, transcription, factor, chordoma, tumor, cell, growth, Other, Transcription, Factors, Degraders, 8168, Tocris Bioscience

篇 DHC-156 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 DHC-156 的引用文献。 您是否知道使用了 Tocris DHC-156 的优秀论文？ 请告知我们.

DHC-156 的评论

目前没有该产品的评论。 Be the first to review DHC-156 and earn rewards!

Have you used DHC-156?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review