Home / Pharmacology / Enzymes / Proteases / Deubiquitinating Enzymes / Deubiquitinating Enzyme Inhibitors / BAY 805

BAY 805

Cat. No. 7984 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective inhibitor of USP21; also NF-κB activator
Chemical Name: N-[(1R)-1-[[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]amino]carbonyl]-3-methylbutyl]-1-(trifluoromethyl)cyclohexanecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for BAY 805

BAY 805 is a potent and selective inhibitor of USP21 (IC50 = 6 nM, Kd = 2.2 nM). BAY 805 induces NF-κB activation (EC50= 17 nM in a cell-based reporter assay).

Technical Data for BAY 805

M. Wt 507.58
Formula C24H28F3N5O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2925481-88-3
PubChem ID 167312463
InChI Key LXRBPWHQMGKMRT-GOSISDBHSA-N
Smiles N#CC(C=C1)=CC=C1CC2=NN=C(S2)NC([C@@H](CC(C)C)NC(C3(CCCCC3)C(F)(F)F)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BAY 805

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.76 100
ethanol 50.76 100

Preparing Stock Solutions for BAY 805

The following data is based on the product molecular weight 507.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL
10 mM 0.2 mL 0.99 mL 1.97 mL
50 mM 0.04 mL 0.2 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for BAY 805

References are publications that support the biological activity of the product.

Göricke et al (2023) Discovery and characterization of BAY-805, a potent and selective inhibitor of ubiquitin-specific protease USP21. J.Med.Chem 66 3431 PMID: 36802665

If you know of a relevant reference for BAY 805, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Deubiquitinating Enzyme Inhibitors

Keywords: BAY 805, BAY 805 supplier, BAY805, inhibitors, inhibits, potent, selective, ubiquitin, specific-processing, protease, ubiquitination, enzymes, deubiquitinating, NF-κB, activation, Deubiquitinating, Enzymes, NF-kB/IkB, 7984, Tocris Bioscience

Citations for BAY 805

Citations are publications that use Tocris products.

Currently there are no citations for BAY 805. Do you know of a great paper that uses BAY 805 from Tocris? Please let us know.

Reviews for BAY 805

There are currently no reviews for this product. Be the first to review BAY 805 and earn rewards!

Have you used BAY 805?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review