Dibutyryl-cAMP, sodium salt

Cat. No. 1141 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cell-permeable cAMP analog

化学名： N⁶,O^2'-Dibutyryl adenosine 3',5'-cyclic monophosphate sodium salt

纯度： ≥98% (HPLC)

引用文献 (4)

实验方案 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Dibutyryl-cAMP, sodium salt

Dibutyryl-cAMP sodium salt is a cell-permeable analog of cAMP that activates cAMP-dependent protein kinases and is a phosphodiesterase inhibitor. Combined with other reagents, dibutyryl-cAMP promotes differentiation of neural stem/progenitor cells (NSPCs) and other cell lines and increases survival rates of NSPCs and differentiation into neurons in vivo. Promotes neurite outgrowth in cell cultures. Dibutyryl-cAMP has anti-inflammatory activity and is used to promote wound healing. Choline acetyltransferase and vesicular acetylcholine transporter mRNA are increased in cells treated with dibutyryl-cAMP.

化合物库 for Dibutyryl-cAMP, sodium salt

Dibutyryl-cAMP, sodium salt is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Dibutyryl-cAMP, sodium salt

分子量	491.37
公式	C₁₈H₂₃N₅NaO₈P
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	16980-89-5
PubChem ID	23663967
InChI Key	KRBZRVBLIUDQNG-JBVYASIDSA-M
Smiles	[Na+].[H][C@@]12COP([O-])(=O)O[C@@]1([H])[C@@H](OC(=O)CCC)[C@@H](O2)N1C=NC2=C1N=CN=C2NC(=O)CCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Dibutyryl-cAMP, sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	49.14	100
	DMSO	49.14	100

制备储备液 for Dibutyryl-cAMP, sodium salt

以下数据基于产品分子量 491.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.18 mL	20.35 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
10 mM	0.2 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

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产品说明书 for Dibutyryl-cAMP, sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Dibutyryl-cAMP, sodium salt

参考文献是支持产品生物活性的出版物。

Carranza et al (1998) Protein kinase A induces recruitment of active Na⁺,K⁺-ATPase units to the plasma membrane of rat proximal convoluted tubule cells. J.Physiol. 511 235 PMID: 9679177

Hei et al (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs Mol.Pharmacol. 39 233 PMID: 1847496

Imamura et al (1998) Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes. Proc.Natl.Acad.Sci.U.S.A. 95 6139 PMID: 9600931

Xia et al (2016) Transcriptional comparison of human induced and primary midbrain DArgic neurons. Sci.Rep. 6 20270 PMID: 26842779

Kim et al (2011) Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS One 6 PMID: 21738784

If you know of a relevant reference for Dibutyryl-cAMP, sodium salt, please let us know.

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